Gene Symbol | CCR8 |
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Entrez Gene | 1237 |
Alt Symbol | CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) receptor 8 |
Other Description | C-C chemokine receptor type 8|CC chemokine receptor 8|CC chemokine receptor CHEMR1|CC-chemokine receptor chemr1|chemokine (C-C) receptor 8|chemokine (C-C) receptor-like 2|chemokine receptor-like 1 |
Swissprots | B2RC64 Q3KNQ8 Q9BYX5 Q3KNR3 P51685 |
Accessions | AAB05542 AAB61962 AAK08628 CAA69712 CAB02142 EAW64577 P51685 AF005210 AAB62547 AK314957 BAG37461 BC069067 AAH69067 BC074743 AAH74743 BC107152 AAI07153 BC107159 AAI07160 D49919 BAA23387 NM_005201 NP_005192 |
Function | Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:9469461, ECO:0000269|PubMed:9521068}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis |
CKR-8 CRISPR/Cas9 KO Plasmid (h) - sc-409596 from Santa Cruz Biotechnology
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CKR-8 HDR Plasmid (h) - sc-409596-HDR from Santa Cruz Biotechnology
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CKR-8 Double Nickase Plasmid (h) - sc-409596-NIC from Santa Cruz Biotechnology
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CKR-8 Double Nickase Plasmid (h2) - sc-409596-NIC-2 from Santa Cruz Biotechnology
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CKR-8 CRISPR Activation Plasmid (h) - sc-409596-ACT from Santa Cruz Biotechnology
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CKR-8 CRISPR Activation Plasmid (h2) - sc-409596-ACT-2 from Santa Cruz Biotechnology
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CKR-8 Lentiviral Activation Particles (h) - sc-409596-LAC from Santa Cruz Biotechnology
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CKR-8 Lentiviral Activation Particles (h2) - sc-409596-LAC-2 from Santa Cruz Biotechnology
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CKR-8 siRNA (h) - sc-39890 from Santa Cruz Biotechnology
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CKR-8 shRNA Plasmid (h) - sc-39890-SH from Santa Cruz Biotechnology
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CKR-8 shRNA (h) Lentiviral Particles - sc-39890-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU009771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5659 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5659 from Sigma-Aldrich
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CCR8 siRNA (Human) - CRH0873 from Cohesion Biosciences
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CCR8 RNAi - H00001237-R02 from Novus Biologicals
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CCR8 - MBS827664 from MyBioSource
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shRNA set against Human CCR8 (NM_005201.3) - SHH258217 from Creative biogene
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Human CCR8 siRNA - orb261375 from Biorbyt
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CCR8 shRNA Plasmid (Human) - CHH0873 from Cohesion Biosciences
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CCR8 miRNA 3'UTR clone - MiUTR4H-TG01834 from Creative biogene
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