IL6ST

Gene Symbol IL6ST
Entrez Gene 3572
Alt Symbol CD130, CDW130, GP130, IL-6RB
Species Human
Gene Type protein-coding
Description interleukin 6 signal transducer
Other Description CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130|membrane glycoprotein gp130|oncostatin-M receptor subunit alpha
Swissprots Q9UQ41 Q5FC04 P40189 A0N0L4
Accessions ABK41905 EAW54936 EAW54937 EAW54938 P40189 AB015706 BAA78112 AB074172 AB102799 BAD89390 AB102800 BAD89391 AB102801 BAD89392 AB102802 BAD89393 AB102803 BAD89394 AB102804 BAD89395 AL049265 AW015107 BC071555 BC117402 AAI17403 BC117404 AAI17405 BC143842 BQ013034 DA863210 DA877322 HQ258523 ADR83277 HQ628629 AER93379 HQ628630 AER93380 M57230 AAA59155 S80479 AAB35921 U58146 AAB63010 XM_011543376 XP_011541678 XM_011543377 XP_011541679 NM_001190981 NP_001177910 NM_002184 NP_002175 NM_175767 NP_786943 NR_120480
Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells

gp130 CRISPR/Cas9 KO Plasmid (h) - sc-400301 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 HDR Plasmid (h) - sc-400301-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 Double Nickase Plasmid (h) - sc-400301-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 Double Nickase Plasmid (h2) - sc-400301-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 CRISPR Activation Plasmid (h) - sc-400301-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 CRISPR Activation Plasmid (h2) - sc-400301-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 Lentiviral Activation Particles (h) - sc-400301-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 Lentiviral Activation Particles (h2) - sc-400301-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

gp130 siRNA (h) - sc-29333 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp130 shRNA Plasmid (h) - sc-29333-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp130 shRNA (h) Lentiviral Particles - sc-29333-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

gp130/CD130 RNAi - H00003572-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU117331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10638 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10638 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07478 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07478

IL6ST siRNA (Human) - CRH2388 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

gp130/CD130 RNAi - H00003572-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IL6ST - MBS8235034 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Il6st (NM_002184.3) - SHH319073 from Creative biogene

Category siRNA
Species Reactivities Human

Human IL6ST siRNA - orb262890 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL6ST shRNA Plasmid (Human) - CHH2388 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL6ST miRNA 3'UTR clone - MiUTR3H-03563 from Creative biogene

Species Reactivities Human

IL6ST miRNA 3'UTR clone - MiUTR3H-03564 from Creative biogene

Species Reactivities Human
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