IL6ST

Gene Symbol IL6ST
Entrez Gene 3572
Alt Symbol CD130, CDW130, GP130, IL-6RB
Species Human
Gene Type protein-coding
Description interleukin 6 signal transducer
Other Description CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130|membrane glycoprotein gp130|oncostatin-M receptor subunit alpha
Swissprots Q9UQ41 Q5FC04 P40189 A0N0L4
Accessions ABK41905 EAW54936 EAW54937 EAW54938 P40189 AB015706 BAA78112 AB074172 AB102799 BAD89390 AB102800 BAD89391 AB102801 BAD89392 AB102802 BAD89393 AB102803 BAD89394 AB102804 BAD89395 AL049265 AW015107 BC071555 BC117402 AAI17403 BC117404 AAI17405 BC143842 BQ013034 DA863210 DA877322 HQ258523 ADR83277 HQ628629 AER93379 HQ628630 AER93380 M57230 AAA59155 S80479 AAB35921 U58146 AAB63010 XM_011543376 XP_011541678 XM_011543377 XP_011541679 NM_001190981 NP_001177910 NM_002184 NP_002175 NM_175767 NP_786943 NR_120480
Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells

GP130 Antibody - 3732 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3, PC12, COS and HeLa cells, using GP130 Antibody.

gp130 (E-8) - sc-376280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gp130 (E-8): sc-376280. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

gp130 (C-20) - sc-655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of gp130 expression in HeLa (A,C) and WEHI-231 (B,D) whole cell lysates. Antibodies tested include gp130 (C-20): sc-655 (A,B) and gp130 (M-20): sc-656 (C,D).

gp130 (H-255) - sc-9045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
gp130 (H-255): sc-9045. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

gp130 (P-18) - sc-32092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

gp130 (M-20) - sc-656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of gp130 expression in HeLa (A,C) and WEHI-231 (B,D) whole cell lysates. Antibodies tested include gp130 (C-20): sc-655 (A,B) and gp130 (M-20): sc-656 (C,D).

gp130 (AN-H2) - sc-9994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
gp130 (AN-H2): sc-9994. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

gp130 (S-16) - sc-32093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-gp130 (D-3) - sc-377570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of gp130 phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) 3T3-L1 whole cell lysates. Antibodies tested include p-gp130 (D-3): sc-377570 (A,B) and gp130 (M-20): sc-656 (C,D).

p-gp130 (A-12) - sc-377572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of gp130 phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) 3T3-L1 whole cell lysates. Antibodies tested include p-gp130 (A-12): sc-377572 (A,B) and gp130 (M-20): sc-656 (C,D).

p-gp130 (Ser 782) - sc-12978 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
gp130 (Ser 782): sc-12978-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic, membrane and nuclear staining of myocytes.

Anti-CD130 (gp130) antibody - ab202850 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human endometrial cancer tissue labeling CD130 (gp130) with ab202850 at 1/100, followed by conjugation to the secondary antibody and DAB staining.

Anti-CD130 (gp130) antibody - ab14491 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD130 (gp130) antibody - ab87969 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-CD130 (gp130) antibody (ab87969) at 1 µg/ml + recombinant protein fragment (the immunogen) at 0.1 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-CD130 (gp130) antibody - ab128618 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD130 (gp130) antibody (ab128618) at 1 µg/ml + MDA-MB-435S cell lysate

Anti-CD130 (gp130) antibody - ab14492 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-CD130 (gp130) antibody [B-K11] - ab27399 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-K11
A typical staining pattern with ab27399 monoclonal antibody of Eahy 926 cell line.

Anti-CD130 (gp130) antibody [B-K5] - ab34324 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-K5

Anti-CD130 (gp130) antibody [B-K5] - ab27354 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-K5
Ab27354, staining CD130 (gp130) of Eahy 926 cell line by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-P4] - ab27357 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-P4
Ab27357, staining CD130 (gp130) of Eahy 926 cell line by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-P8] - ab27355 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-P8
Ab27355, staining CD130 (gp130) of Eahy 926 cell line by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-R3] - ab34315 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-R3

Anti-CD130 (gp130) antibody [B-R3] - ab47217 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-R3
Ab47217, staining CD130 (gp130) by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-R3] - ab47216 from Abcam

Prices $376.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-R3
Ab47216, at a dilution of 10µl for 106 cells or 100 µl of whole blood, staining CD130 (gp130) by Flow Cytometry.

Anti-CD130 (gp130) antibody [B-R3] (FITC) - ab47218 from Abcam

Prices $189.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone B-R3
Ab47218, at a dilution of 10µl for 106 cells or 100 µl of whole blood, staining CD130 (gp130) by Flow Cytometry.
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