| Gene Symbol |
SCRIB
|
| Entrez Gene |
23513
|
| Alt Symbol |
CRIB1, SCRB1, SCRIB1, Vartul
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
scribbled planar cell polarity protein
|
| Other Description |
protein scribble homolog|scribbled homolog
|
| Swissprots |
Q14160 Q8WWV8 Q6P496 Q96C69 Q7Z5D1 Q96GG1
|
| Accessions |
EAW82196 EAW82197 EAW82198 Q14160 AF240677 AAP88017 AF271734 AAP88018 AF318352 AAL55859 AI829609 AY062238 AAL38976 BC009490 AAH09490 BC014632 AAH14632 BC026045 BC036905 BC044627 AAH44627 BC063590 BC146321 AAI46322 D63481 BAA09768 NM_015356 NP_056171 NM_182706 NP_874365
|
| Function |
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. {ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:15775968, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
|
| Tissue Specificity |
Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). {ECO:0000269|PubMed:15806148}.
|
| Top Pathways |
Viral carcinogenesis, Hippo signaling pathway
|