Gene Symbol | RPH3AL |
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Entrez Gene | 9501 |
Alt Symbol | NOC2 |
Species | Human |
Gene Type | protein-coding |
Description | rabphilin 3A-like (without C2 domains) |
Other Description | no C2 domains protein|rab effector Noc2 |
Swissprots | Q9BSB3 Q9UNE2 D3DTG7 |
Accessions | EAW90669 EAW90670 EAW90671 EAW90672 Q9UNE2 AF129812 AAD45582 AK000469 BAA91186 AK291950 BAF84639 BC005153 AAH05153 BC093776 AAH93776 BC113413 AAI13414 BC143311 BF507559 BP275333 BU197069 BU568991 DA378956 HQ258174 ADR82928 XM_011535364 XP_011533666 XM_011535365 XP_011533667 XM_011535366 XP_011533668 XM_011535367 XP_011533669 XM_011535368 XP_011533670 XM_011535369 XP_011533671 XM_011546997 XP_011545299 XM_011546998 XP_011545300 XM_011546999 XP_011545301 XM_011547000 XP_011545302 XM_011547001 XP_011545303 XM_011547002 XP_011545304 XM_011547003 XP_011545305 XR_942191 XR_952112 NM_001190411 NP_001177340 NM_001190412 NP_001177341 NM_001190413 NP_001177342 NM_006987 NP_008918 |
Function | Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15003533}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15003533}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15003533}. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells. |
Tissue Specificity | Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells. {ECO:0000269|PubMed:10395805, ECO:0000269|PubMed:15003533}. |
rabphilin-3AL CRISPR/Cas9 KO Plasmid (h) - sc-417977 from Santa Cruz Biotechnology
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rabphilin-3AL HDR Plasmid (h) - sc-417977-HDR from Santa Cruz Biotechnology
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rabphilin-3AL Double Nickase Plasmid (h) - sc-417977-NIC from Santa Cruz Biotechnology
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rabphilin-3AL Double Nickase Plasmid (h2) - sc-417977-NIC-2 from Santa Cruz Biotechnology
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rabphilin-3AL CRISPR Activation Plasmid (h) - sc-417977-ACT from Santa Cruz Biotechnology
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rabphilin-3AL CRISPR Activation Plasmid (h2) - sc-417977-ACT-2 from Santa Cruz Biotechnology
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rabphilin-3AL Lentiviral Activation Particles (h) - sc-417977-LAC from Santa Cruz Biotechnology
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rabphilin-3AL Lentiviral Activation Particles (h2) - sc-417977-LAC-2 from Santa Cruz Biotechnology
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rabphilin-3AL siRNA (h) - sc-94036 from Santa Cruz Biotechnology
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rabphilin-3AL shRNA Plasmid (h) - sc-94036-SH from Santa Cruz Biotechnology
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rabphilin-3AL shRNA (h) Lentiviral Particles - sc-94036-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN18531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18531 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09407 from Sigma-Aldrich
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RPH3AL siRNA (Human) - CRH6310 from Cohesion Biosciences
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RPH3AL RNAi - H00009501-R01 from Novus Biologicals
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RPH3AL - MBS8221848 from MyBioSource
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shRNA set against Human RPH3AL (NM_006987.3) - SHH398028 from Creative biogene
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RPH3AL shRNA Plasmid (Human) - CHH6310 from Cohesion Biosciences
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RPH3AL miRNA 3'UTR clone - MiUTR3H-07158 from Creative biogene
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