Gene Symbol | THRA |
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Entrez Gene | 7067 |
Alt Symbol | AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1 |
Species | Human |
Gene Type | protein-coding |
Description | thyroid hormone receptor, alpha |
Other Description | EAR-7|ERBA-related 7|V-erbA-related protein 7|c-erbA-alpha|nuclear receptor subfamily 1 group A member 1|thyroid hormone receptor alpha|thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)|thyroid normone nuclear receptor alpha variant 1|triiodothyronine receptor |
Swissprots | A8K3B5 Q96H73 Q8N6A1 P10827 P21205 |
Accessions | AAA66021 CAA38899 CAB57886 EAW60632 EAW60633 EAW60634 P10827 AB209346 BAD92583 AB307686 BAH02277 AF522368 AAM77692 AK290071 BAF82760 AK290530 BAF83219 AK311344 BC000261 AAH00261 BC002728 AAH02728 BC008851 AAH08851 BC035137 AAH35137 BQ224043 CR541915 CAG46713 DQ892512 ABM83438 DQ895726 ABM86652 HQ692859 ADZ17370 J03239 AAA61176 M24899 AAA35783 M24900 AAA52333 X55005 CAA38749 Y00479 CAA68539 NM_001190918 NP_001177847 NM_001190919 NP_001177848 NM_003250 NP_003241 NM_199334 NP_955366 |
Function | Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}. |
Subcellular Location | Nucleus. |
Top Pathways | Neuroactive ligand-receptor interaction |
TRα CRISPR/Cas9 KO Plasmid (h) - sc-401475 from Santa Cruz Biotechnology
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TRα HDR Plasmid (h) - sc-401475-HDR from Santa Cruz Biotechnology
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TRα Double Nickase Plasmid (h) - sc-401475-NIC from Santa Cruz Biotechnology
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TRα Double Nickase Plasmid (h2) - sc-401475-NIC-2 from Santa Cruz Biotechnology
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TRα CRISPR Activation Plasmid (h) - sc-401475-ACT from Santa Cruz Biotechnology
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TRα CRISPR Activation Plasmid (h2) - sc-401475-ACT-2 from Santa Cruz Biotechnology
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TRα Lentiviral Activation Particles (h) - sc-401475-LAC from Santa Cruz Biotechnology
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TRα Lentiviral Activation Particles (h2) - sc-401475-LAC-2 from Santa Cruz Biotechnology
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TRα siRNA (h) - sc-36707 from Santa Cruz Biotechnology
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TRα shRNA Plasmid (h) - sc-36707-SH from Santa Cruz Biotechnology
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TRα shRNA (h) Lentiviral Particles - sc-36707-V from Santa Cruz Biotechnology
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TR alpha/NR1A1/Thyroid Hormone Receptor alpha RNAi - H00007067-R02 from Novus Biologicals
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MISSION® esiRNA - EHU013761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21323 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21323 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04299 from Sigma-Aldrich
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THRA siRNA (Human) - CRH4836 from Cohesion Biosciences
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TR alpha/NR1A1/Thyroid Hormone Receptor alpha RNAi - H00007067-R01 from Novus Biologicals
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THRA - MBS827923 from MyBioSource
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shRNA set against Human THRA(NM_001190918.1) - SHH223008 from Creative biogene
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Human THRA siRNA - orb265338 from Biorbyt
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THRA shRNA Plasmid (Human) - CHH4836 from Cohesion Biosciences
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THRA miRNA 3'UTR clone - MiUTR1H-10387 from Creative biogene
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THRA miRNA 3'UTR clone - MiUTR3H-02273 from Creative biogene
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THRA miRNA 3'UTR clone - MiUTR3H-02274 from Creative biogene
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