COL2A1

Gene Symbol COL2A1
Entrez Gene 1280
Alt Symbol ANFH, AOM, COL11A3, SEDC, STL1
Species Human
Gene Type protein-coding
Description collagen, type II, alpha 1
Other Description alpha-1 type II collagen|arthroophthalmopathy, progressive (Stickler syndrome)|cartilage collagen|chondrocalcin|collagen II, alpha-1 polypeptide|collagen alpha-1(II) chain
Swissprots Q14044 Q6LBY3 Q14045 Q96IT5 Q9UE43 A6NGA0 Q2V4X7 Q14046 P02458 Q14009 Q9UE40 Q9UE38 Q6LBY1 Q14056 Q1JQ82 Q6LBY2 Q9UE41 Q9UE39 Q12985 Q14058 Q99227 Q9UE42 Q14047 Q16672
Accessions AAA51997 AAA52037 AAA52039 AAA52051 AAA58428 AAA73873 AAB60370 AAC41772 AAD14239 AAD15286 AAD15287 CAA25092 CAA26223 CAA26224 CAA26225 CAA26226 CAA26227 CAA27041 CAA34278 CAA34279 CAA34280 CAA34281 CAA34282 CAA34283 CAA34284 CAA40330 CAI61687 CDM55396 CDM55577 EAW57966 EAW57967 EAW57968 EAW57969 EAW57970 P02458 AL834148 CAI46208 BC007252 AAH07252 BC116449 AAI16450 BT007205 AAP35869 HG504715 HG504716 LN608441 M63281 AAA52038 X06268 CAA29604 X13783 CAA32030 X16468 CAA34488 X16711 CAA34683 XM_006719242 XP_006719305 XM_011537928 XP_011536230 XM_011537929 XP_011536231 XM_011537930 XP_011536232 XM_011537931 XP_011536233 XM_011537932 XP_011536234 XM_011537933 XP_011536235 XM_011537934 XP_011536236 XM_011537935 XP_011536237 NM_001844 NP_001835 NM_033150 NP_149162
Function Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Tissue Specificity Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. {ECO:0000269|PubMed:2355003}.
Top Pathways Focal adhesion, ECM-receptor interaction, Amoebiasis, Protein digestion and absorption, PI3K-Akt signaling pathway

COL2A1 (H-300) - sc-28887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
COL2A1 (H-300): sc-28887. Western blot analysis of COL2A1 expression in CCD-1064Sk whole cell lysate.

COL2A1 (N-19) - sc-7764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COL2A1 (N-19): sc-7764. Western blot analysis of COL2A1 expression in HT-1080 (A) and CCD-1064Sk (B) whole cell lysates.

COL2A1 (C-19) - sc-7763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

COL2A1 (M2193) - sc-52658 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
COL2A1 (M2193): sc-52658. Western blot analysis of COL2A1 expression in CCD-1064Sk whole cell lysate.

Anti-Collagen II antibody - ab116242 from Abcam

Prices $373.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Collagen II antibody - ab85266 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Collagen II staining in Human normal colon FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab85266, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-Collagen II antibody - ab24128 from Abcam

Host Goat
Clonality Polyclonal

Anti-Collagen II antibody - ab75622 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab75622, at a dilution of 1/10, staining Collagen II in formalin fixed and paraffin embedded human hepatocarcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was then used, followed by DAB staining.

Anti-Collagen II antibody - ab24118 from Abcam

Prices $370.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-Collagen II antibody [EPR12268] - ab188570 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12268
Anti-Collagen II antibody [EPR12268] (ab188570) at 1/5000 dilution + Human cartilage at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-procollagen type IIA antibody - ab17771 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ab17771, at a 1/1000 dilution, staining fetal bone anlage in the hand (around week 10) by IHC-P.

Anti-COL2A1 / Collagen II Alpha 1 Antibody (clone 1E1) - LS-C139303 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E1

Anti-COL2A1 / Collagen II Alpha 1 Antibody (Internal) - LS-C210055 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, Biotin) - LS-C276387 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, FITC) - LS-C276388 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, AP) - LS-C276386 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, APC) - LS-C276385 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, Azide-free, HRP) - LS-C276389 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus, Biotin) - LS-C276393 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (aa476-505, PE) - LS-C276390 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus, APC) - LS-C276392 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus, AP) - LS-C276391 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus, FITC) - LS-C276394 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus, Azide-free, HRP) - LS-C276395 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COL2A1 / Collagen II Alpha 1 Antibody (C-Terminus) - LS-C98125 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-COL2A1 Antibody (RB13830) in 293 cell line lysates (35 ug/lane). COL2A1(arrow) was detected using the purified antibody.
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