COL2A1

Gene Symbol	COL2A1
Entrez Gene	1280
Alt Symbol	ANFH, AOM, COL11A3, SEDC, STL1
Species	Human
Gene Type	protein-coding
Description	collagen, type II, alpha 1
Other Description	alpha-1 type II collagen|arthroophthalmopathy, progressive (Stickler syndrome)|cartilage collagen|chondrocalcin|collagen II, alpha-1 polypeptide|collagen alpha-1(II) chain
Swissprots	Q14044 Q6LBY3 Q14045 Q96IT5 Q9UE43 A6NGA0 Q2V4X7 Q14046 P02458 Q14009 Q9UE40 Q9UE38 Q6LBY1 Q14056 Q1JQ82 Q6LBY2 Q9UE41 Q9UE39 Q12985 Q14058 Q99227 Q9UE42 Q14047 Q16672
Accessions	AAA51997 AAA52037 AAA52039 AAA52051 AAA58428 AAA73873 AAB60370 AAC41772 AAD14239 AAD15286 AAD15287 CAA25092 CAA26223 CAA26224 CAA26225 CAA26226 CAA26227 CAA27041 CAA34278 CAA34279 CAA34280 CAA34281 CAA34282 CAA34283 CAA34284 CAA40330 CAI61687 CDM55396 CDM55577 EAW57966 EAW57967 EAW57968 EAW57969 EAW57970 P02458 AL834148 CAI46208 BC007252 AAH07252 BC116449 AAI16450 BT007205 AAP35869 HG504715 HG504716 LN608441 M63281 AAA52038 X06268 CAA29604 X13783 CAA32030 X16468 CAA34488 X16711 CAA34683 XM_006719242 XP_006719305 XM_011537928 XP_011536230 XM_011537929 XP_011536231 XM_011537930 XP_011536232 XM_011537931 XP_011536233 XM_011537932 XP_011536234 XM_011537933 XP_011536235 XM_011537934 XP_011536236 XM_011537935 XP_011536237 NM_001844 NP_001835 NM_033150 NP_149162
Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Tissue Specificity	Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. {ECO:0000269|PubMed:2355003}.
Top Pathways	Focal adhesion, ECM-receptor interaction, Amoebiasis, Protein digestion and absorption, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Collagen II peptide - ab105995 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Cow Collagen II full length protein - ab7527 from Abcam Category Protein Prices $235.00 Sizes 500 µg Source Native Species Bovine

Cow Collagen II full length protein - ab134539 from Abcam Category Protein Source Native Species Bovine

Cow Collagen II full length protein - ab134530 from Abcam Category Protein Source Native Species Bovine

Human Collagen II full length protein - ab7534 from Abcam Category Protein Source Native Species Human

Human Collagen II full length protein - ab134522 from Abcam Category Protein Source Native Species Human

Human Collagen II full length protein - ab134534 from Abcam Category Protein Source Native Species Human

Human procollagen type IIA full length protein - ab158154 from Abcam Category Protein Source Wheat germ Species Human

COL2A1 / Collagen II Alpha 1 Antibody Blocking Peptide - LS-E3054 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Collagen II Protein - H00001280-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Collagen II Protein - NBP1-97301 from Novus Biologicals Category Protein Species Human

Collagen II Peptide - P0384 from Novus Biologicals Category Peptide Species Human

Collagen II Protein - P4917 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 1 mg Species Human

Collagen II Human Expressed Protein - P4916 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 1 mg Species Human

COL2A1-Antibody-C-term-Blocking-Peptide - BP1418b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Pro-Collagen II, CF - 7589-CL-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln26-Arg266 & Gly957-Leu1487, with an N-terminal 5-His tag

Collagen Type II protein - 30R-AC015 from Fitzgerald Category Protein Prices $795.00 Sizes 100 µg

Collagen type II alpha 1 chain (Adult Knee Cartilage) - RA003 from Acris Antibodies Category Protein Prices $680.00 Sizes 100 µg Source Cartilage Species Human

Collagen type II alpha 1 chain - H00001280-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Collagen type II alpha 1 chain - H00001280-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Collagen type II alpha 1 chain - P4916 from Acris Antibodies Category Protein Prices $840.00 Sizes 1 mg Species Human

Collagen type II alpha 1 chain - P4917 from Acris Antibodies Category Protein Prices $840.00 Sizes 1 mg Species Human

Collagen Type II Alpha 1 (COL2a1), Human - 20-8711 from ARP American Research Products Category Protein Prices $511.00 Sizes 50 µg Source E.coli Species Human

COL2A1 Recombinant Protein - 96-195 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

COL2A1 fusion protein - Ag8416 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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