Gene Symbol | AGBL3 |
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Entrez Gene | 340351 |
Alt Symbol | CCP3 |
Species | Human |
Gene Type | protein-coding |
Description | ATP/GTP binding protein-like 3 |
Other Description | ATP/GTP-binding protein-like 3|cytosolic carboxypeptidase 3 |
Swissprots | Q9H965 Q8NEM8 B7Z827 |
Accessions | EAW83837 EAW83838 Q8NEM8 AA707617 AK021841 AK023045 BAB14371 AK302827 BAH13813 AK311252 AL832281 BC030651 AAH30651 XM_011516119 XP_011514421 XM_011516120 XP_011514422 XM_011516121 XP_011514423 XM_011516122 XP_011514424 NM_178563 NP_848658 |
Function | Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy- terminus of tubulin. {ECO:0000269|PubMed:17244817}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CDP0}. |
CCP3 CRISPR/Cas9 KO Plasmid (h) - sc-415538 from Santa Cruz Biotechnology
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CCP3 HDR Plasmid (h) - sc-415538-HDR from Santa Cruz Biotechnology
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CCP3 Double Nickase Plasmid (h) - sc-415538-NIC from Santa Cruz Biotechnology
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CCP3 Double Nickase Plasmid (h2) - sc-415538-NIC-2 from Santa Cruz Biotechnology
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CCP3 CRISPR Activation Plasmid (h) - sc-415538-ACT from Santa Cruz Biotechnology
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CCP3 CRISPR Activation Plasmid (h2) - sc-415538-ACT-2 from Santa Cruz Biotechnology
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CCP3 Lentiviral Activation Particles (h) - sc-415538-LAC from Santa Cruz Biotechnology
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CCP3 Lentiviral Activation Particles (h2) - sc-415538-LAC-2 from Santa Cruz Biotechnology
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CCP3 siRNA (h) - sc-89741 from Santa Cruz Biotechnology
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CCP3 shRNA Plasmid (h) - sc-89741-SH from Santa Cruz Biotechnology
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CCP3 shRNA (h) Lentiviral Particles - sc-89741-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN2938 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2938 from Sigma-Aldrich
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AGBL3 siRNA (Human) - CRJ7340 from Cohesion Biosciences
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AGBL3 - MBS8232495 from MyBioSource
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shRNA set against Human AGBL3 (NM_178563.3) - SHH233198 from Creative biogene
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Human AGBL3 siRNA - orb277841 from Biorbyt
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AGBL3 shRNA Plasmid (Human) - CHJ7340 from Cohesion Biosciences
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AGBL3 miRNA 3'UTR clone - MiUTR3H-13532 from Creative biogene
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