PTF1A

Gene Symbol	PTF1A
Entrez Gene	256297
Alt Symbol	PACA, PAGEN2, PTF1-p48, bHLHa29
Species	Human
Gene Type	protein-coding
Description	pancreas specific transcription factor, 1a
Other Description	bHLH transcription factor p48|class A basic helix-loop-helix protein 29|class II bHLH protein PTF1A|exocrine pancreas-specific transcription factor p48|p48 DNA-binding subunit of transcription factor PTF1|pancreas transcription factor 1 subunit alpha|pancreas-specific transcription factor 1a
Swissprots	Q7RTS3 Q9HC25
Accessions	DAA01052 Q7RTS3 AF181999 AAG09441 BC172252 AAI72252 BC172557 AAI72557 BM055347 CK904916 NM_178161 NP_835455
Function	Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269|PubMed:10768861, ECO:0000269|PubMed:15543146}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity). {ECO:0000250}.
Tissue Specificity	Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers. {ECO:0000269|PubMed:10768861}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Pancreas Specific Transcription Factor 1a, PTF1a, Human, ELISA Kit - E-EL-H2241 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Pancreas Specific Transcription Factor 1a, PTF1a, Rabbit, ELISA Kit - E-EL-RB0458 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, PTF1a, Chicken, ELISA Kit - E-EL-Ch1429 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, PTF1a, Porcine, ELISA Kit - E-EL-P0787 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, PTF1a, Sheep, ELISA Kit - E-EL-S0222 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, PTF1a, Guinea Pig, ELISA Kit - E-EL-GP1051 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, PTF1a, Monkey, ELISA Kit - E-EL-MK1236 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS744964 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS033038 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS720966 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS073054 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS092515 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS725097 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS016242 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS752757 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS726138 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS043669 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Pancreas Specific Transcription Factor 1A, ELISA Kit - MBS047000 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pancreas Specific Transcription Factor 1a, ELISA Kit - MBS746140 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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