PTF1A

Gene Symbol	PTF1A
Entrez Gene	256297
Alt Symbol	PACA, PAGEN2, PTF1-p48, bHLHa29
Species	Human
Gene Type	protein-coding
Description	pancreas specific transcription factor, 1a
Other Description	bHLH transcription factor p48|class A basic helix-loop-helix protein 29|class II bHLH protein PTF1A|exocrine pancreas-specific transcription factor p48|p48 DNA-binding subunit of transcription factor PTF1|pancreas transcription factor 1 subunit alpha|pancreas-specific transcription factor 1a
Swissprots	Q7RTS3 Q9HC25
Accessions	DAA01052 Q7RTS3 AF181999 AAG09441 BC172252 AAI72252 BC172557 AAI72557 BM055347 CK904916 NM_178161 NP_835455
Function	Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269|PubMed:10768861, ECO:0000269|PubMed:15543146}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity). {ECO:0000250}.
Tissue Specificity	Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers. {ECO:0000269|PubMed:10768861}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

PTF1A Antibody Blocking Peptide - LS-E2778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTF1A Antibody Blocking Peptide - LS-E11413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTF1A Antibody Blocking Peptide - LS-E26432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTF1A Antibody Blocking Peptide - LS-E26366 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTF1A Antibody Blocking Peptide - LS-E13352 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTF1A-Antibody-C-term-Blocking-peptide - BP13876b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ptf1a Immunizing peptide - orb50305 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PTF1A Immunizing peptide - orb17062 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human PTF1a Protein - abx068415 from Abbexa Category Protein Source E.coli Species Human

PTF1A Peptide - AC21-1201-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PTF1A Peptide - AC21-1271-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Pancreas Specific Transcription Factor 1a (PTF1a), Human - 20-8568 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

PTF1a Peptide - 46-247P from ProSci Category Peptide Species Human, Mouse

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Pancreas Specific Transcription Factor 1a (PTF1a) - RPC738Hu03 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Pancreas transcription factor 1 subunit alpha(PTF1A) - CSB-YP752531HU CSB-EP752531HU CSB-BP752531HU CSB-MP752531HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Pancreas Specific Transcription Factor 1a (PTF1a), Recombinant Protein - MBS2010585 from MyBioSource Category Protein Prices $200.00, $430.00, $665.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Pancreas transcription factor 1 subunit alpha (PTF1A), Recombinant Protein - MBS1289152 from MyBioSource Category Protein Prices $1,090.00, $1,090.00, $1,320.00, $1,320.00, $1,715.00, $1,715.00, $2,180.00, $2,180.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PTF1A/PFT1-P48, Peptide - MBS425390 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Zebrafish

Ptf1a-Blocking-Peptide-C-term - BP2706b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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