| Gene Symbol | CACNA1D |
|---|---|
| Entrez Gene | 776 |
| Alt Symbol | CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, L type, alpha 1D subunit |
| Other Description | calcium channel, L type, alpha-1 polypeptide|calcium channel, neuroendocrine/brain-type, alpha 1 subunit|voltage-dependent L-type calcium channel subunit alpha-1D|voltage-gated calcium channel alpha 1 subunit|voltage-gated calcium channel alpha subunit Cav1.3 |
| Swissprots | Q71UT1 Q13916 Q9UDC3 Q01668 Q13931 B0FYA3 |
| Accessions | AAD08651 BAA07804 EAW65286 EAW65287 EAW65288 EAW65289 EAW65290 EAW65291 EAW65292 EAW65293 EAW65294 EAW65295 Q01668 AB209171 BAD92408 AK294397 BAH11755 AK294585 BAG57776 AW008794 EU363339 ABY66526 M76558 AAA58402 M83566 AAA35629 XM_005265448 XP_005265505 XM_011534094 XP_011532396 XM_011534095 XP_011532397 XM_011534096 XP_011532398 XM_011534097 XP_011532399 XM_011534098 XP_011532400 XM_011534099 XP_011532401 XM_011534100 XP_011532402 NM_000720 NP_000711 NM_001128839 NP_001122311 NM_001128840 NP_001122312 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO:0000269|PubMed:18482979}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:18482979}; Multi-pass membrane protein {ECO:0000269|PubMed:18482979}. |
| Tissue Specificity | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. {ECO:0000269|PubMed:1335101}. |
| Top Pathways | Oxytocin signaling pathway, Calcium signaling pathway, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Circadian entrainment |
L-type Ca ++ CP α1D CRISPR/Cas9 KO Plasmid (h) - sc-401745 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D HDR Plasmid (h) - sc-401745-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D Double Nickase Plasmid (h) - sc-401745-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D Double Nickase Plasmid (h2) - sc-401745-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D CRISPR Activation Plasmid (h) - sc-401745-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D CRISPR Activation Plasmid (h2) - sc-401745-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D Lentiviral Activation Particles (h) - sc-401745-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D Lentiviral Activation Particles (h2) - sc-401745-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D siRNA (h) - sc-42690 from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D shRNA Plasmid (h) - sc-42690-SH from Santa Cruz Biotechnology
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L-type Ca ++ CP α1D shRNA (h) Lentiviral Particles - sc-42690-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5263 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5263 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04463 from Sigma-Aldrich
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CACNA1D siRNA (Human) - CRH0541 from Cohesion Biosciences
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Cav1.3 RNAi - H00000776-R01 from Novus Biologicals
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CACNA1D - MBS8227418 from MyBioSource
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shRNA set against Human CACNA1D (NM_000720.2) - SHH253285 from Creative biogene
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shRNA set against Human CACNA1D(NM_000720.2) - SHG133067 from Creative biogene
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CACNA1D shRNA Plasmid (Human) - CHH0541 from Cohesion Biosciences
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CACNA1D miRNA 3'UTR clone - MiUTR1H-01593 from Creative biogene
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CACNA1D miRNA 3'UTR clone - MiUTR3H-00320 from Creative biogene
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CACNA1D miRNA 3'UTR clone - MiUTR3H-00321 from Creative biogene
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