CACNA1D

Gene Symbol CACNA1D
Entrez Gene 776
Alt Symbol CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, L type, alpha 1D subunit
Other Description calcium channel, L type, alpha-1 polypeptide|calcium channel, neuroendocrine/brain-type, alpha 1 subunit|voltage-dependent L-type calcium channel subunit alpha-1D|voltage-gated calcium channel alpha 1 subunit|voltage-gated calcium channel alpha subunit Cav1.3
Swissprots Q71UT1 Q13916 Q9UDC3 Q01668 Q13931 B0FYA3
Accessions AAD08651 BAA07804 EAW65286 EAW65287 EAW65288 EAW65289 EAW65290 EAW65291 EAW65292 EAW65293 EAW65294 EAW65295 Q01668 AB209171 BAD92408 AK294397 BAH11755 AK294585 BAG57776 AW008794 EU363339 ABY66526 M76558 AAA58402 M83566 AAA35629 XM_005265448 XP_005265505 XM_011534094 XP_011532396 XM_011534095 XP_011532397 XM_011534096 XP_011532398 XM_011534097 XP_011532399 XM_011534098 XP_011532400 XM_011534099 XP_011532401 XM_011534100 XP_011532402 NM_000720 NP_000711 NM_001128839 NP_001122311 NM_001128840 NP_001122312
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO:0000269|PubMed:18482979}.
Subcellular Location Membrane {ECO:0000269|PubMed:18482979}; Multi-pass membrane protein {ECO:0000269|PubMed:18482979}.
Tissue Specificity Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. {ECO:0000269|PubMed:1335101}.
Top Pathways Oxytocin signaling pathway, Calcium signaling pathway, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Circadian entrainment

L-type Ca ++ CP α1D (E-19) - sc-32072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α1D (E-19): sc-32072. Western blot analysis of L-type Ca<sup>++</sup> CP α1D expression in L6 (A), C6 (B), IMR-32 (C), SK-N-SH (D) and U-87 MG (E) whole cell lysates.

L-type Ca ++ CP α1D (C-20) - sc-16251 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L-type Cα<sup>++</sup> CP α1D (C-20): sc-16251. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing membrane and cytoplasmic staining of glandular cells.

L-type Ca ++ CP α1D (F-20) - sc-32070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L-type Ca<sup>++ </sup>CP α1D (F-20): sc-32070. Immunoperoxi-dase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and membrane staining of cells in seminiferous ducts and cytoplasmic staining of Leydig cells.

L-type Ca ++ CP α1D (H-20) - sc-32071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α1D (H-20): sc-32071. Western blot analysis of L-type Ca<sup>++</sup> CP α1D expression in non-transfected: sc-117752 (A) and truncated mouse L-type Ca<sup>++</sup> CP α1D transfected: sc-121266 (B) 293T whole cell lysates.

L-type Ca ++ CP α1D (H-240) - sc-25687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α1D (H-240): sc-25687. Western blot analysis of L-type Ca<sup>++</sup> CP α1D expression in L6 whole cell lysate.

L-type Ca ++ CP α1S/1C/1D/1F (H-300) - sc-98753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α1S/1C/1D/1F (H-300): sc-98753. Western blot analysis of L-type Ca<sup>++</sup> CP α1S/1C/1D/1F expression in mouse heart tissue extract.

Anti-CaV1.3 antibody - ab81096 from Abcam

Host Rabbit
Clonality Polyclonal
IHC image of CaV1.3 staining in human cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab81096, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-CaV1.3 antibody [S38-8] - ab84811 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S38-8
ab84811 staining CaV1.3 in human hippocampal tissue by IHC-P (Bouin's fixed paraffin embedded).

Anti-CaV1.3 antibody [S48A-9] - ab85491 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9
ab85491 staining CaV1.3 in mouse backskin tissue by IHC-P (Bouin's fixed paraffin embedded tissue sections). Tissue underwent antigen retrieval using microwave in citrate buffer. The primary antibody was used at 1/100 dilution and then sections were incubated with Fluorophore conjugated goat anti mouse at 1/50 dilution.

Anti-CaV1.3 antibody [S48A-9] (Biotin) - ab183407 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CaV1.3 antibody [S48A-9] (FITC) - ab183405 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CaV1.3 antibody [S48A-9] (HRP) - ab183406 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CaV1.3 antibody - C-terminal - ab191038 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CaV1.3 antibody - C-terminal (ab191038) at 0.5 µg/ml + Rat brain tissue lysate at 40 µg

Anti-CACNA1D / Cav1.3 Antibody (Cytoplasmic Domain) - LS-C94028 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1D / Cav1.3 Antibody - LS-C183373 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 390) - LS-C230589 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 565) - LS-C230590 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 488) - LS-C230591 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 633) - LS-C230593 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa2025-2161, clone S38-8) - LS-C109001 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S38-8
IHC analysis of CACNA1D / Cav1.3 antibody on frozen mouse brain.

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 594) - LS-C230592 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 655) - LS-C230594 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 680) - LS-C230595 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, AP) - LS-C230597 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9

Anti-CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9, Atto 700) - LS-C230596 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S48A-9
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