| Gene Symbol | HLCS |
|---|---|
| Entrez Gene | 3141 |
| Alt Symbol | HCS |
| Species | Human |
| Gene Type | protein-coding |
| Description | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) |
| Other Description | biotin apo-protein ligase|biotin--[acetyl-CoA-carboxylase] ligase|biotin--[methylcrotonoyl-CoA-carboxylase] ligase|biotin--[methylmalonyl-CoA-carboxytransferase] ligase|biotin--protein ligase|holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) |
| Swissprots | B2RAH1 D3DSG6 P50747 Q99451 |
| Accessions | BAA89434 BAA95510 BAA95511 BAB68550 EAX09731 EAX09732 P50747 AJ001864 CAA05056 AK307940 AK314189 BAG36868 BC060787 AAH60787 BI094308 BQ775124 CB049233 D23672 BAA04902 D87328 BAA13332 DA334377 DB290499 H17102 X80160 XM_005260953 XP_005261010 XM_005260954 XP_005261011 XM_005260955 XP_005261012 XM_005260956 XP_005261013 XM_006723994 XP_006724057 XM_006723995 XP_006724058 XM_011529538 XP_011527840 XM_011529539 XP_011527841 XM_011529540 XP_011527842 XM_011529541 XP_011527843 XM_011529542 XP_011527844 NM_000411 NP_000402 NM_001242784 NP_001229713 NM_001242785 NP_001229714 |
| Function | Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase. |
| Subcellular Location | Cytoplasm. Mitochondrion. |
| Tissue Specificity | Mostly expressed in muscle, placenta, in lesser extent in the brain, kidney, pancreas, liver and lung. |
| Top Pathways | Biotin metabolism |