Hspa1a
| Gene Symbol | Hspa1a |
|---|---|
| Entrez Gene | 193740 |
| Alt Symbol | Hsp70-3, Hsp70.3, Hsp72, hsp68, hsp70A1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | heat shock protein 1A |
| Other Description | 68 kDa heat shock protein|heat shock 70 kDa protein 1A|heat shock 70 kDa protein 3|heat shock 70kDa protein 1A|heat shock protein, 70 kDa 3|inducible heat shock protein 70 |
| Swissprots | Q9QWJ5 Q61697 Q61696 Q7TQD8 |
| Accessions | AAA57233 AAC84169 ABK96811 BAA32523 BAA32525 EDL26710 Q61696 AK132331 AK160912 BAE36086 AK171820 BAE42680 BC032044 BC054782 AAH54782 BC157921 AAI57922 M12571 AAA57234 M12572 AAA57235 NM_010479 NP_034609 |
| Function | In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. {ECO:0000250|UniProtKB:P08107}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}. |
| Top Pathways | Toxoplasmosis, Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A |
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