Gene Symbol | TFIP11 |
---|---|
Entrez Gene | 24144 |
Alt Symbol | NTR1, Spp382, TIP39, bK445C9.6, hNtr1 |
Species | Human |
Gene Type | protein-coding |
Description | tuftelin interacting protein 11 |
Other Description | STIP-1|septin and tuftelin-interacting protein 1|tuftelin-interacting protein 11 |
Swissprots | Q9Y2Q8 Q9UBB9 Q9UGV7 Q5H8V8 O95908 Q20WL0 |
Accessions | CAI17878 CAQ09360 EAW59722 EAW59723 EAW59724 Q9UBB9 AF070662 AAD20968 AK025443 AK025739 AK298303 BAG60557 AK299964 BAG61790 AL050258 CAB43360 AL080147 CAB45740 AM393087 CAL37965 BC011599 AAH11599 BC033080 AAH33080 BT007274 AAP35938 BX354919 CT841511 CAJ86441 CU012962 CAK54393 CU013250 CAK54692 DQ892251 ABM83177 DQ896849 ABM87848 XM_011530079 XP_011528381 NM_001008697 NP_001008697 NM_012143 NP_036275 |
Function | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}. |