TFIP11
| Gene Symbol | TFIP11 |
|---|---|
| Entrez Gene | 24144 |
| Alt Symbol | NTR1, Spp382, TIP39, bK445C9.6, hNtr1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tuftelin interacting protein 11 |
| Other Description | STIP-1|septin and tuftelin-interacting protein 1|tuftelin-interacting protein 11 |
| Swissprots | Q9Y2Q8 Q9UBB9 Q9UGV7 Q5H8V8 O95908 Q20WL0 |
| Accessions | CAI17878 CAQ09360 EAW59722 EAW59723 EAW59724 Q9UBB9 AF070662 AAD20968 AK025443 AK025739 AK298303 BAG60557 AK299964 BAG61790 AL050258 CAB43360 AL080147 CAB45740 AM393087 CAL37965 BC011599 AAH11599 BC033080 AAH33080 BT007274 AAP35938 BX354919 CT841511 CAJ86441 CU012962 CAK54393 CU013250 CAK54692 DQ892251 ABM83177 DQ896849 ABM87848 XM_011530079 XP_011528381 NM_001008697 NP_001008697 NM_012143 NP_036275 |
| Function | Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}. |
TFIP11 CRISPR/Cas9 KO Plasmid (h) - sc-407684 from Santa Cruz Biotechnology
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TFIP11 HDR Plasmid (h) - sc-407684-HDR from Santa Cruz Biotechnology
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TFIP11 Double Nickase Plasmid (h) - sc-407684-NIC from Santa Cruz Biotechnology
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TFIP11 Double Nickase Plasmid (h2) - sc-407684-NIC-2 from Santa Cruz Biotechnology
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TFIP11 CRISPR Activation Plasmid (h) - sc-407684-ACT from Santa Cruz Biotechnology
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TFIP11 CRISPR Activation Plasmid (h2) - sc-407684-ACT-2 from Santa Cruz Biotechnology
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TFIP11 Lentiviral Activation Particles (h) - sc-407684-LAC from Santa Cruz Biotechnology
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TFIP11 Lentiviral Activation Particles (h2) - sc-407684-LAC-2 from Santa Cruz Biotechnology
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TFIP11 siRNA (h) - sc-76671 from Santa Cruz Biotechnology
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TFIP11 shRNA Plasmid (h) - sc-76671-SH from Santa Cruz Biotechnology
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TFIP11 shRNA (h) Lentiviral Particles - sc-76671-V from Santa Cruz Biotechnology
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TFIP11 RNAi - H00024144-R01 from Novus Biologicals
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TFIP11 RNAi - H00024144-R02 from Novus Biologicals
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MISSION® esiRNA - EHU045061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21263 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21263 from Sigma-Aldrich
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TFIP11 siRNA (Human) - CRH8472 from Cohesion Biosciences
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TFIP11 - MBS8224393 from MyBioSource
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shRNA set against Human TFIP11(NM_012143.2) - SHL067188 from Creative biogene
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shRNA set against Human TFIP11(NM_001008697.1) - SHL067230 from Creative biogene
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TFIP11 shRNA Plasmid (Human) - CHH8472 from Cohesion Biosciences
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TFIP11 miRNA 3'UTR clone - MiUTR1H-10343 from Creative biogene
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TFIP11 miRNA 3'UTR clone - MiUTR1H-10344 from Creative biogene
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