TNFSF10

Gene Symbol	TNFSF10
Entrez Gene	8743
Alt Symbol	APO2L, Apo-2L, CD253, TL2, TRAIL
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 10
Other Description	Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|chemokine tumor necrosis factor ligand superfamily member 10|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta|tumor necrosis factor ligand superfamily member 10
Swissprots	A1Y9B3 P50591
Accessions	ABK41891 CAH68809 CAL33971 CAZ39545 CCA94584 EAW78465 EAW78466 EAW78467 P50591 AK296085 BAG58840 AK309200 AK312742 BAG35612 AY312579 AAR16184 BC009795 BC020220 BC032722 AAH32722 BT019564 AAV38371 CR456895 CAG33176 DA041872 DA969653 DQ848564 ABI24016 DQ890873 ABM81799 DQ894029 ABM84955 EU183231 ABW24658 U37518 AAC50332 U57059 AAB01233 NM_001190942 NP_001177871 NM_001190943 NP_001177872 NM_003810 NP_003801 NR_033994
Function	Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Widespread; most predominant in spleen, lung and prostate.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TRAIL protein fragment - ab157345 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Active human TRAIL protein fragment - ab109360 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Active human TRAIL protein fragment - ab157018 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human TRAIL protein fragment - ab168898 from Abcam Category Protein Prices $643.00, $2,374.00 Sizes 20 µg, 500 µg Source E. coli Species Human

Active human TRAIL protein fragment - ab55764 from Abcam Category Protein Prices $302.00 Sizes 50 µg Source E. coli Species Human

Active mouse TRAIL protein fragment - ab117234 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source E. coli Species Mouse

Active TRAIL full length protein - ab9960 from Abcam Category Protein Prices $239.00 Sizes 50 µg Source E. coli

Human TRAIL full length protein - ab192126 from Abcam Category Protein Source E. coli Species Human

Human TRAIL peptide - ab42241 from Abcam Category Peptide

Human TRAIL peptide - ab42242 from Abcam Category Peptide

Human TRAIL protein fragment - ab169885 from Abcam Category Protein Source E. coli Species Human

Human TRAIL protein fragment - ab78818 from Abcam Category Protein Source E. coli Species Human

TRAIL peptide - ab2436 from Abcam Category Peptide

TRAIL peptide - ab7867 from Abcam Category Peptide

TNFSF10 / TRAIL Antibody Blocking Peptide - LS-E10659 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFSF10 / TRAIL Antibody Blocking Peptide - LS-E29838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TRAIL/TNFSF10 Protein - H00008743-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TRAIL/TNFSF10 Protein - NBC1-18505 from Novus Biologicals Category Protein Prices $529.00 Sizes 500 µg Species Human

TRAIL/TNFSF10 Recombinant Protein - P4442 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Human

TRAIL/TNFSF10 Blocking Peptide - NBP1-77062PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TRAIL/TNFSF10 Recombinant Protein - NBP1-94699 from Novus Biologicals Category Protein Prices $529.00 Sizes 50 µg Species Human

TRAIL/TNFSF10 Protein - NBP1-99139 from Novus Biologicals Category Protein Species Human

TRAIL/TNFSF10 Protein - NBP1-99351 from Novus Biologicals Category Protein Prices $309.00 Sizes 50 µg Species Human

TRAIL/TNFSF10 Recombinant Protein - H00008743-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

TRAIL-Antibody-Center-N109-Blocking-peptide - BP12271c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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