KIAA0101
| Gene Symbol | KIAA0101 |
|---|---|
| Entrez Gene | 9768 |
| Alt Symbol | L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF |
| Species | Human |
| Gene Type | protein-coding |
| Description | KIAA0101 |
| Other Description | HCV NS5A-transactivated protein 9|PCNA-associated factor|PCNA-associated factor of 15 kDa|hepatitis C virus NS5A-transactivated protein 9|overexpressed in anaplastic thyroid carcinoma 1 |
| Swissprots | Q15004 A6NNU5 A8K3Y3 G9G696 G9G694 |
| Accessions | AEW89488 AEW89489 AEW89490 AEW89491 AEW89492 AEW89493 AEW89494 AEW89495 AEW89496 AEW89497 AEW89498 AEW89499 AEW89500 AEW89501 AEW89502 AEW89503 AEW89504 AEW89505 AEW89506 AEW89507 AEW89508 AEW89509 AEW89510 AEW89511 AEW89512 AEW89513 AEW89514 AEW89515 AEW89516 AEW89517 AEW89518 AEW89519 AEW89520 AEW89521 AEW89522 AEW89523 AEW89524 AEW89525 AEW89526 AEW89527 AEW89528 AEW89529 AEW89530 AEW89531 AEW89532 AEW89533 AEW89534 AEW89535 AEW89536 AEW89537 AEW89538 AEW89539 AEW89540 AEW89541 AEW89542 AEW89543 AEW89544 AEW89545 AEW89546 AEW89547 AEW89548 AEW89549 AEW89550 AEW89551 AEW89552 AEW89553 AEW89554 AEW89555 AEW89556 AEW89557 AEW89558 AEW89559 AEW89560 AEW89561 AEW89562 AEW89563 AEW89564 AEW89565 AEW89566 AEW89567 AEW89568 AEW89569 AEW89570 AEW89571 AEW89572 AEW89573 AEW89574 AEW89575 AEW89576 AEW89577 AEW89578 AEW89579 AEW89580 AEW89581 AEW89582 AEW89583 AEW89584 AEW89585 AEW89586 AEW89587 AEW89588 AEW89589 AEW89590 AEW89591 AEW89592 AEW89593 AEW89594 AEW89595 AEW89596 AEW89597 EAW77679 EAW77680 EAW77681 Q15004 AF529370 AAQ09604 AK290748 BAF83437 AV757440 AY598324 AAT06735 BC005832 AAH05832 BC007101 AAH07101 BC016782 AAH16782 BF691807 BG502841 D14657 BAA03491 DT220867 HQ447907 ADQ32391 NM_001029989 NP_001025160 NM_014736 NP_055551 NR_109934 |
| Function | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Subcellular Location | Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region. |
| Tissue Specificity | Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small- cell lung cancer lines. {ECO:0000269|PubMed:11313979, ECO:0000269|PubMed:15789362, ECO:0000269|PubMed:22096502}. |
p15 (PAF) CRISPR/Cas9 KO Plasmid (h) - sc-402724 from Santa Cruz Biotechnology
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p15 (PAF) HDR Plasmid (h) - sc-402724-HDR from Santa Cruz Biotechnology
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p15 (PAF) Double Nickase Plasmid (h) - sc-402724-NIC from Santa Cruz Biotechnology
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p15 (PAF) Double Nickase Plasmid (h2) - sc-402724-NIC-2 from Santa Cruz Biotechnology
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p15 (PAF) CRISPR Activation Plasmid (h) - sc-402724-ACT from Santa Cruz Biotechnology
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p15 (PAF) CRISPR Activation Plasmid (h2) - sc-402724-ACT-2 from Santa Cruz Biotechnology
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p15 (PAF) Lentiviral Activation Particles (h) - sc-402724-LAC from Santa Cruz Biotechnology
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p15 (PAF) Lentiviral Activation Particles (h2) - sc-402724-LAC-2 from Santa Cruz Biotechnology
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p15 (PAF) siRNA (h) - sc-62735 from Santa Cruz Biotechnology
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p15 shRNA Plasmid (PAF) shRNA Plasmid (h) - sc-62735-SH from Santa Cruz Biotechnology
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p15 (PAF) shRNA (h) Lentiviral Particles - sc-62735-V from Santa Cruz Biotechnology
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PCNA associated factor RNAi - H00009768-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11056 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11056 from Sigma-Aldrich
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KIAA0101 siRNA (Human) - CRH6532 from Cohesion Biosciences
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PCNA associated factor RNAi - H00009768-R02 from Novus Biologicals
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shRNA set against Human KIAA0101 (NM_014736.4) - SHH324479 from Creative biogene
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shRNA set against Human KIAA0101(NM_001029989.1) - SHR023080 from Creative biogene
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Human KIAA0101 siRNA - orb267034 from Biorbyt
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KIAA0101 shRNA Plasmid (Human) - CHH6532 from Cohesion Biosciences
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KIAA0101 miRNA 3'UTR clone - MiUTR1H-05198 from Creative biogene
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KIAA0101 miRNA 3'UTR clone - MiUTR1H-05199 from Creative biogene
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