| Gene Symbol | ST6GAL2 |
|---|---|
| Entrez Gene | 84620 |
| Alt Symbol | SIAT2, ST6GalII |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2|alpha 2,6-ST 2|beta-galactoside alpha-2,6-sialyltransferase 2|beta-galactoside alpha-2,6-sialyltransferase II|sialyltransferase 2 (monosialoganglioside sialyltransferase) |
| Swissprots | D3DVK3 Q96HE4 Q8IUG7 Q96JF0 Q86Y44 Q53QP4 |
| Accessions | AAY15022 CAS91680 EAX01742 EAX01743 Q96JF0 AB058780 BAB47506 AB059555 BAC24793 AJ512141 CAD54408 AK055273 AK095049 AK095653 AK307784 BC008680 AAH08680 BQ016989 CN365495 DA176100 FJ433883 ACQ63561 FJ433884 ACQ63562 FJ433885 ACQ63563 JF432175 ADZ15392 XM_006712801 XP_006712864 XM_006712802 XP_006712865 XM_011511999 XP_011510301 XM_011512000 XP_011510302 XM_011512001 XP_011510303 XM_011512002 XP_011510304 XM_011512003 XP_011510305 XR_923046 NM_001142351 NP_001135823 NM_001142352 NP_001135824 NM_032528 NP_115917 |
| Function | Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Weakly expressed in some tissues, such as small intestine, colon and fetal brain. {ECO:0000269|PubMed:12235148, ECO:0000269|PubMed:12603328}. |
| Top Pathways | N-Glycan biosynthesis, Other types of O-glycan biosynthesis |