Gene Symbol | CDC42EP2 |
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Entrez Gene | 10435 |
Alt Symbol | BORG1, CEP2 |
Species | Human |
Gene Type | protein-coding |
Description | CDC42 effector protein (Rho GTPase binding) 2 |
Other Description | CRIB-containing BOGR1 protein|binder of Rho GTPases 1|cdc42 effector protein 2 |
Swissprots | Q9UNS0 B2RD85 O14613 |
Accessions | AAN39381 EAW74374 O14613 AF001436 AAB81206 AF098290 AAD16185 AF163840 AAD48784 AK098292 BAG53607 AK315444 BAG37832 BC022337 AAH22337 BC075834 AAH75834 BT020004 AAV38807 DA251345 DQ891988 ABM82914 DQ895178 ABM86104 NM_006779 NP_006770 |
Function | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}. |
Tissue Specificity | Highly expressed in the heart. Weakly expressed in the pancreas and liver. {ECO:0000269|PubMed:10490598}. |
Cdc42EP2 CRISPR/Cas9 KO Plasmid (h) - sc-408520 from Santa Cruz Biotechnology
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Cdc42EP2 HDR Plasmid (h) - sc-408520-HDR from Santa Cruz Biotechnology
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Cdc42EP2 Double Nickase Plasmid (h) - sc-408520-NIC from Santa Cruz Biotechnology
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Cdc42EP2 Double Nickase Plasmid (h2) - sc-408520-NIC-2 from Santa Cruz Biotechnology
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Cdc42EP2 CRISPR Activation Plasmid (h) - sc-408520-ACT from Santa Cruz Biotechnology
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Cdc42EP2 CRISPR Activation Plasmid (h2) - sc-408520-ACT-2 from Santa Cruz Biotechnology
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Cdc42EP2 Lentiviral Activation Particles (h) - sc-408520-LAC from Santa Cruz Biotechnology
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Cdc42EP2 Lentiviral Activation Particles (h2) - sc-408520-LAC-2 from Santa Cruz Biotechnology
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Cdc42EP2 siRNA (h) - sc-96953 from Santa Cruz Biotechnology
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Cdc42EP2 shRNA Plasmid (h) - sc-96953-SH from Santa Cruz Biotechnology
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Cdc42EP2 shRNA (h) Lentiviral Particles - sc-96953-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU015981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5787 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5787 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06531 from Sigma-Aldrich
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CDC42EP2 siRNA (Human) - CRH7077 from Cohesion Biosciences
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CDC42EP2 RNAi - H00010435-R01 from Novus Biologicals
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CDC42EP2 - MBS8205640 from MyBioSource
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shRNA set against Human CDC42EP2 (NM_006779.3) - SHH259869 from Creative biogene
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Human CDC42EP2 siRNA - orb267579 from Biorbyt
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CDC42EP2 shRNA Plasmid (Human) - CHH7077 from Cohesion Biosciences
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CDC42EP2 miRNA 3'UTR clone - MiUTR3H-08239 from Creative biogene
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