Gene Symbol |
AGBL2
|
Entrez Gene |
79841
|
Alt Symbol |
CCP2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
ATP/GTP binding protein-like 2
|
Other Description |
cytoplasmic carboxypeptidase 2|cytosolic carboxypeptidase 2
|
Swissprots |
Q8IV57 Q53FV5 Q5U5Z8 A8MPX2 Q9H5C0
|
Accessions |
EAW67889 EAW67890 EAW67891 Q5U5Z8 AK027251 BAB15707 AK056687 AK223171 BAD96891 AK223176 BAD96896 AK303066 BAG64183 AK303875 BAG64813 BC028200 AAH28200 BC036234 AAH36234 XM_005253138 XP_005253195 XM_005253139 XP_005253196 XM_005253140 XP_005253197 XM_005253141 XP_005253198 XM_006718327 XP_006718390 XM_006718328 XP_006718391 XM_011520372 XP_011518674 XM_011520373 XP_011518675 XM_011520374 XP_011518676 XM_011520375 XP_011518677 XM_011520376 XP_011518678 XM_011520377 XP_011518679 XM_011520378 XP_011518680 XM_011520379 XP_011518681 XM_011520380 XP_011518682 XM_011520381 XP_011518683 XM_011520382 XP_011518684 XR_242823 XR_242824 XR_428852 XR_930908 XR_930909 XR_930910 XR_930911 NM_024783 NP_079059
|
Function |
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. {ECO:0000250|UniProtKB:Q8CDK2}.
|
Subcellular Location |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CDK2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}.
|