Gene Symbol | AGBL2 |
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Entrez Gene | 79841 |
Alt Symbol | CCP2 |
Species | Human |
Gene Type | protein-coding |
Description | ATP/GTP binding protein-like 2 |
Other Description | cytoplasmic carboxypeptidase 2|cytosolic carboxypeptidase 2 |
Swissprots | Q8IV57 Q53FV5 Q5U5Z8 A8MPX2 Q9H5C0 |
Accessions | EAW67889 EAW67890 EAW67891 Q5U5Z8 AK027251 BAB15707 AK056687 AK223171 BAD96891 AK223176 BAD96896 AK303066 BAG64183 AK303875 BAG64813 BC028200 AAH28200 BC036234 AAH36234 XM_005253138 XP_005253195 XM_005253139 XP_005253196 XM_005253140 XP_005253197 XM_005253141 XP_005253198 XM_006718327 XP_006718390 XM_006718328 XP_006718391 XM_011520372 XP_011518674 XM_011520373 XP_011518675 XM_011520374 XP_011518676 XM_011520375 XP_011518677 XM_011520376 XP_011518678 XM_011520377 XP_011518679 XM_011520378 XP_011518680 XM_011520379 XP_011518681 XM_011520380 XP_011518682 XM_011520381 XP_011518683 XM_011520382 XP_011518684 XR_242823 XR_242824 XR_428852 XR_930908 XR_930909 XR_930910 XR_930911 NM_024783 NP_079059 |
Function | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. {ECO:0000250|UniProtKB:Q8CDK2}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CDK2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}. |
CCP2 CRISPR/Cas9 KO Plasmid (h) - sc-410133 from Santa Cruz Biotechnology
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CCP2 HDR Plasmid (h) - sc-410133-HDR from Santa Cruz Biotechnology
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CCP2 Double Nickase Plasmid (h) - sc-410133-NIC from Santa Cruz Biotechnology
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CCP2 Double Nickase Plasmid (h2) - sc-410133-NIC-2 from Santa Cruz Biotechnology
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CCP2 CRISPR Activation Plasmid (h) - sc-410133-ACT from Santa Cruz Biotechnology
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CCP2 CRISPR Activation Plasmid (h2) - sc-410133-ACT-2 from Santa Cruz Biotechnology
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CCP2 Lentiviral Activation Particles (h) - sc-410133-LAC from Santa Cruz Biotechnology
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CCP2 Lentiviral Activation Particles (h2) - sc-410133-LAC-2 from Santa Cruz Biotechnology
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CCP2 siRNA (h) - sc-96960 from Santa Cruz Biotechnology
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CCP2 shRNA Plasmid (h) - sc-96960-SH from Santa Cruz Biotechnology
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CCP2 shRNA (h) Lentiviral Particles - sc-96960-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2937 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2937 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04873 from Sigma-Aldrich
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AGBL2 siRNA (Human) - CRJ2605 from Cohesion Biosciences
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AGBL2 - MBS8202157 from MyBioSource
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shRNA set against Human AGBL2 (NM_024783.3) - SHH233186 from Creative biogene
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Human AGBL2 siRNA - orb273106 from Biorbyt
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AGBL2 shRNA Plasmid (Human) - CHJ2605 from Cohesion Biosciences
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AGBL2 miRNA 3'UTR clone - MiUTR4H-TG00204 from Creative biogene
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