MEGF10

Gene Symbol	MEGF10
Entrez Gene	84466
Alt Symbol	EMARDD
Species	Human
Gene Type	protein-coding
Description	multiple EGF-like-domains 10
Other Description	multiple epidermal growth factor-like domains protein 10
Swissprots	Q68DE5 Q8WUL3 Q96KG7
Accessions	EAW62406 EAW62407 Q96KG7 AB058676 BAB47409 AK021631 AK123568 AK307919 BC020198 AAH20198 BC152478 AAI52479 CR749437 CAH18275 DA240513 DA738723 XM_011543692 XP_011541994 XM_011543693 XP_011541995 XM_011543694 XP_011541996 XM_011543695 XP_011541997 NM_001256545 NP_001243474 NM_001308119 NP_001295048 NM_001308121 NP_001295050 NM_032446 NP_115822
Function	Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway. {ECO:0000269|PubMed:17498693, ECO:0000269|PubMed:17643423, ECO:0000269|PubMed:20828568, ECO:0000269|PubMed:22101682}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Note=Enriched at the sites of contact with apoptotic thymocyte cells (By similarity). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MEGF10 (S-18) - sc-54244 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEGF10 (H-62) - sc-134993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MEGF10 (C-18) - sc-54243 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MEGF10 (A-20) - sc-54242 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Megf10 antibody - ab121894 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Antibody - NBP1-93576 from Novus Biologicals Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody - bs-12372R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12372R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12372R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12372R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12372R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, Cy3 Conjugated - bs-12372R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, Cy5 Conjugated - bs-12372R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, Cy5.5 Conjugated - bs-12372R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, Cy7 Conjugated - bs-12372R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, FITC Conjugated - bs-12372R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-MEGF10 Polyclonal Antibody, PE Conjugated - bs-12372R-PE from Bioss Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, Biotin Conjugated - bs-12372R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 Polyclonal Antibody, HRP Conjugated - bs-12372R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MEGF10 antibody produced in rabbit - HPA026876 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MEGF10 antibody - orb157861 from Biorbyt Prices $255.00, $340.00 Sizes 100 μg, 200 μg Host Rabbit Clonality Polyclonal

Rabbit Anti-Human MEGF10 Polyclonal Antibody - DPABH-20215 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Anti-MEGF10 monoclonal antibody - DCABH-200937 from Creative Diagnostics Host Rabbit Clonality Monoclonal

MEGF10 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-12372R-A594 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MEGF10 antibody - STJ112531 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

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