| Gene Symbol |
MEGF10
|
| Entrez Gene |
84466
|
| Alt Symbol |
EMARDD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
multiple EGF-like-domains 10
|
| Other Description |
multiple epidermal growth factor-like domains protein 10
|
| Swissprots |
Q68DE5 Q8WUL3 Q96KG7
|
| Accessions |
EAW62406 EAW62407 Q96KG7 AB058676 BAB47409 AK021631 AK123568 AK307919 BC020198 AAH20198 BC152478 AAI52479 CR749437 CAH18275 DA240513 DA738723 XM_011543692 XP_011541994 XM_011543693 XP_011541995 XM_011543694 XP_011541996 XM_011543695 XP_011541997 NM_001256545 NP_001243474 NM_001308119 NP_001295048 NM_001308121 NP_001295050 NM_032446 NP_115822
|
| Function |
Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway. {ECO:0000269|PubMed:17498693, ECO:0000269|PubMed:17643423, ECO:0000269|PubMed:20828568, ECO:0000269|PubMed:22101682}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Note=Enriched at the sites of contact with apoptotic thymocyte cells (By similarity). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11. {ECO:0000250}.
|