| Gene Symbol |
DAGLA
|
| Entrez Gene |
747
|
| Alt Symbol |
C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol lipase, alpha
|
| Other Description |
DGL-alpha|neural stem cell-derived dendrite regulator|sn1-specific diacylglycerol lipase alpha
|
| Swissprots |
Q6WQJ0 Q9Y4D2 A7E233
|
| Accessions |
EAW73959 EAW73960 EAW73961 EAW73962 Q9Y4D2 AB014559 BAA31634 AI702626 AY275377 AAQ17119 BC150176 AAI50177 BC150195 AAI50196 BC152453 AAI52454 BI963857 XM_005274230 XP_005274287 XM_011545235 XP_011543537 XM_011545236 XP_011543538 NM_006133 NP_006124
|
| Function |
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269|PubMed:14610053}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in brain and pancreas. {ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:16051747}.
|
| Top Pathways |
Retrograde endocannabinoid signaling
|