Gene Symbol | L3HYPDH |
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Entrez Gene | 112849 |
Alt Symbol | C14orf149 |
Species | Human |
Gene Type | protein-coding |
Description | L-3-hydroxyproline dehydratase (trans-) |
Other Description | probable proline racemase|trans-3-hydroxy-L-proline dehydratase|trans-3-hydroxy-l-proline dehydratase|trans-3-hydroxyl-L-proline dehydratase|trans-L-3-hydroxyproline dehydratase |
Swissprots | Q96LJ5 Q96EM0 |
Accessions | EAW80752 Q96EM0 AK058165 BAB71696 AK294843 BAG57949 BC012131 AAH12131 XM_005267298 XP_005267355 XM_011536386 XP_011534688 XM_011536387 XP_011534689 XM_011536388 XP_011534690 XR_245661 XR_943382 XR_943383 XR_943384 XR_943385 XR_943386 NM_144581 NP_653182 |
Function | Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. {ECO:0000269|PubMed:22528483}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:22528483}. |
Top Pathways | Arginine and proline metabolism |
L3HYPDH CRISPR/Cas9 KO Plasmid (h) - sc-414009 from Santa Cruz Biotechnology
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L3HYPDH HDR Plasmid (h) - sc-414009-HDR from Santa Cruz Biotechnology
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L3HYPDH Double Nickase Plasmid (h) - sc-414009-NIC from Santa Cruz Biotechnology
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L3HYPDH Double Nickase Plasmid (h2) - sc-414009-NIC-2 from Santa Cruz Biotechnology
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C14orf149 CRISPR Activation Plasmid (h) - sc-414009-ACT from Santa Cruz Biotechnology
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L3HYPDH CRISPR Activation Plasmid (h2) - sc-414009-ACT-2 from Santa Cruz Biotechnology
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L3HYPDH Lentiviral Activation Particles (h) - sc-414009-LAC from Santa Cruz Biotechnology
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L3HYPDH Lentiviral Activation Particles (h2) - sc-414009-LAC-2 from Santa Cruz Biotechnology
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L3HYPDH siRNA (h) - sc-92402 from Santa Cruz Biotechnology
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L3HYPDH shRNA Plasmid (h) - sc-92402-SH from Santa Cruz Biotechnology
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L3HYPDH shRNA (h) Lentiviral Particles - sc-92402-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4326 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4326 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01958 from Sigma-Aldrich
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L3HYPDH siRNA (Human) - CRJ4295 from Cohesion Biosciences
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shRNA set against Human C14orf149 (NM_144581.1) - SHH249378 from Creative biogene
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Human L3HYPDH siRNA - orb274796 from Biorbyt
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L3HYPDH shRNA Plasmid (Human) - CHJ4295 from Cohesion Biosciences
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L3HYPDH miRNA 3'UTR clone - MiUTR1H-01103 from Creative biogene
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