Gene Symbol | IQCB1 |
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Entrez Gene | 9657 |
Alt Symbol | NPHP5, PIQ, SLSN5 |
Species | Human |
Gene Type | protein-coding |
Description | IQ motif containing B1 |
Other Description | IQ calmodulin-binding motif containing 1|IQ calmodulin-binding motif-containing protein 1|nephrocystin 5|p53 and DNA damage-regulated IQ motif protein |
Swissprots | Q8NI79 Q5DKQ7 Q9BS08 Q3KS09 Q3KS08 Q15051 |
Accessions | EAW79499 EAW79500 EAW79501 Q15051 AB062481 BAB93506 AL042102 AY714228 AAW47233 AY964667 AAY46029 AY964668 AAY46030 BC005806 AAH05806 BG721354 BM682018 BQ068103 BX393165 D25278 BAA04968 XM_005247911 XP_005247968 XM_005247912 XP_005247969 XM_005247913 XP_005247970 XM_011513335 XP_011511637 XR_924221 NM_001023570 NP_001018864 NM_001023571 NP_001018865 |
Function | Involved in ciliogenesis. {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Note=Localization to the centrosome depends on the interaction with CEP290. |
Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors. {ECO:0000269|PubMed:15723066, ECO:0000269|PubMed:16322217}. |
nephrocystin-5 CRISPR/Cas9 KO Plasmid (h) - sc-407054 from Santa Cruz Biotechnology
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nephrocystin-5 HDR Plasmid (h) - sc-407054-HDR from Santa Cruz Biotechnology
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nephrocystin-5 Double Nickase Plasmid (h) - sc-407054-NIC from Santa Cruz Biotechnology
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nephrocystin-5 Double Nickase Plasmid (h2) - sc-407054-NIC-2 from Santa Cruz Biotechnology
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nephrocystin-5 CRISPR Activation Plasmid (h) - sc-407054-ACT from Santa Cruz Biotechnology
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nephrocystin-5 CRISPR Activation Plasmid (h2) - sc-407054-ACT-2 from Santa Cruz Biotechnology
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nephrocystin-5 Lentiviral Activation Particles (h) - sc-407054-LAC from Santa Cruz Biotechnology
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nephrocystin-5 Lentiviral Activation Particles (h2) - sc-407054-LAC-2 from Santa Cruz Biotechnology
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nephrocystin-5 siRNA (h) - sc-72270 from Santa Cruz Biotechnology
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nephrocystin-5 shRNA Plasmid (h) - sc-72270-SH from Santa Cruz Biotechnology
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nephrocystin-5 shRNA (h) Lentiviral Particles - sc-72270-V from Santa Cruz Biotechnology
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IQCB1 RNAi - H00009657-R02 from Novus Biologicals
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MISSION® esiRNA - EHU099411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10740 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10740 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02672 from Sigma-Aldrich
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IQCB1 siRNA (Human) - CRH6434 from Cohesion Biosciences
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IQCB1 RNAi - H00009657-R01 from Novus Biologicals
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IQCB1 - MBS8232439 from MyBioSource
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shRNA set against Human IQCB1 (NM_001023570.2) - SHH320273 from Creative biogene
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Human IQCB1 siRNA - orb266936 from Biorbyt
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IQCB1 shRNA Plasmid (Human) - CHH6434 from Cohesion Biosciences
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IQCB1 miRNA 3'UTR clone - MiUTR3H-10499 from Creative biogene
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IQCB1 miRNA 3'UTR clone - MiUTR3H-10500 from Creative biogene
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