PAX6

Gene Symbol	PAX6
Entrez Gene	5080
Alt Symbol	AN, AN2, D11S812E, FVH1, MGDA, WAGR
Species	Human
Gene Type	protein-coding
Description	paired box 6
Other Description	aniridia type II protein|oculorhombin|paired box homeotic gene-6|paired box protein Pax-6
Swissprots	Q99413 P26367 Q6N006
Accessions	AAB30690 AAB30691 AAB30692 AAN86817 AAO27433 AAP57671 AAP74576 AAR10412 AAR10413 AAS44593 AAS44594 ABB55262 ABB55263 ADP65746 EAW68233 EAW68234 EAW68235 EAW68236 P26367 AB209177 BAD92414 AB593092 BAJ84032 AB593093 BAJ84033 AB593094 BAJ84034 AK074881 BAG52023 AK094172 AK094249 AK314470 AY047583 AAK95849 AY707088 AAU12168 BC011953 AAH11953 BE221553 BI789171 BI816814 BM313099 BM557761 BM725029 BP394398 BP394576 BU072567 BX089704 BX114225 BX440968 BX640762 CAE45868 CA397536 CD673930 CV569250 DA078958 DA079367 DA141443 DA183294 DQ891436 ABM82362 DQ894612 ABM85538 F07809 GQ141695 ACZ28705 KP255960 M77844 AAA59962 M93650 AAA36416 XM_005252954 XP_005253011 XM_005252955 XP_005253012 XM_005252956 XP_005253013 XM_005252958 XP_005253015 XM_006718246 XP_006718309 XM_011520146 XP_011518448 XM_011520147 XP_011518449 XM_011520148 XP_011518450 XM_011520149 XP_011518451 XM_011520150 XP_011518452 XM_011520151 XP_011518453 XM_011520152 XP_011518454 XM_011520153 XP_011518455 NM_000280 NP_000271 NM_001127612 NP_001121084 NM_001258462 NP_001245391 NM_001258463 NP_001245392 NM_001258464 NP_001245393 NM_001258465 NP_001245394 NM_001604 NP_001595
Function	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. {ECO:0000250}.
Subcellular Location	Nucleus.
Tissue Specificity	Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Top Pathways	Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PAX6 full length protein - ab131997 from Abcam Category Protein Source Wheat germ Species Human

Human PAX6 full length protein - ab134885 from Abcam Category Protein Source E. coli Species Human

Human PAX6 protein fragment - ab98302 from Abcam Category Protein Source E. coli Species Human

PAX6 peptide - ab5895 from Abcam Category Peptide

PAX6 peptide - ab90840 from Abcam Category Peptide

PAX6 Antibody Blocking Peptide - LS-E11514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAX6 Antibody Blocking Peptide - LS-E13652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAX6 Antibody Blocking Peptide - LS-E26335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAX6 Antibody Blocking Peptide - LS-E8553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAX6 Antibody Blocking Peptide - LS-E8554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Pax6 Protein - H00005080-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Pax6 Protein - H00005080-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PAX6-T373-Antibody-Blocking-Peptide - BP6929d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAX6-Antibody-Center-Blocking-Peptide - BP6929c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAX6 Blocking Peptide - 33R-10848 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PAX6 Peptide - AC21-1170-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PAX6 - H00005080-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PAX6 - H00005080-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PAX6 - H00005080-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAX6 - H00005080-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAX6 Control Peptide - SP5290CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PAX6 Peptide - 46-140P from ProSci Category Peptide Species Mouse

PAX6 fusion protein - ag16024 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PAX6 fusion protein - ag19014 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PAX6 fusion protein - ag2984 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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