SGK3

Gene Symbol SGK3
Entrez Gene 23678
Alt Symbol CISK, SGK2, SGKL
Species Human
Gene Type protein-coding
Description serum/glucocorticoid regulated kinase family, member 3
Other Description cytokine-independent survival kinase|serine/threonine-protein kinase Sgk3
Swissprots B3KQC2 A8K5W3 Q96BR1 Q9P1Q7 Q9UKG5
Accessions CAF86721 CBX51345 EAW86919 EAW86920 Q96BR1 AF085233 AAF27051 AF169035 AAF12758 AI127772 AK074666 BAG51984 AK223523 BAD97243 AK291428 BAF84117 AV714643 BC015326 AAH15326 BF665552 BI547053 BM739201 BQ777590 BU177012 CB995805 CK822899 CR536581 CAG38818 CR933673 CAI45969 DB447859 NM_001033578 NP_001028750 NM_013257 NP_037389 NM_170709 NP_733827
Function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and
Subcellular Location Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Tissue Specificity Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER- positive breast tumors than ER-negative breast tumors. {ECO:0000269|PubMed:21084382}.
Top Pathways PI3K-Akt signaling pathway

Phospho-SGK3 (Thr320) (D30E6) Rabbit mAb - 5642 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D30E6
Western blot analysis of extracts from COS-7 cells, untransfected or transfected with human SGK3, and untreated or treated with calf intestinal phosphatase (CIP), using Phospho-SGK3 (Thr320) (D30E6) Rabbit mAb (upper) or SGK3 Antibody #4227 (lower).

SGK3 (D42C2) Rabbit mAb - 8573 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D42C2
Western blot analysis of extracts from various cell lines using SGK3 (D42C2) Rabbit mAb.

SGK3 (D18D1) Rabbit mAb - 8156 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D18D1
Western blot analysis of extracts from various cell lines using SGK3 (D18D1) Rabbit mAb.

SGK3 Antibody - 4227 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells, untransfected or transfected with human or mouse SGK3, using SGK3 Antibody.

SGK3 (C-6) - sc-166847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SGK3 (C-6): sc-166847. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

SGK3 (G-17) - sc-47394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SGK3 (G-17): sc-47394. Western blot analysis of SGK3 expression in MIA PaCa-2 (A), KNRK (B), Hep G2 (C) and Caki-1 (D) whole cell lysates and mouse kidney tissue extract (E).

SGK3 (H-95) - sc-98973 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SGK3 (H-95): sc-98973. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

SGK3 (N-17) - sc-47396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SGK3 (N-17): sc-47396. Western blot analysis of SGK3 expression in HeLa whole cell lysate.

SGK3 (X-22) - sc-130874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
SGK3 (X-22): sc-130874. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.

p-SGK3 (Ser 486) - sc-33044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (N-Terminus) IHC-plus™ - LS-A7230 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SGK3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SGK3 Antibody (C-Terminus) - LS-C135345 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SGK3 antibody LS-C135345 Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml.

Anti-SGK3 Antibody (phospho-Thr320, clone D30E6) - LS-C184122 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone D30E6

Anti-SGK3 Antibody (aa381-409, FITC) - LS-C240680 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa381-409, AP) - LS-C240681 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa381-409, Biotin) - LS-C240682 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa381-409, PE) - LS-C240683 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa7-36, AP) - LS-C240684 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa7-36, APC) - LS-C240685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa7-36, FITC) - LS-C240686 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa7-36, Biotin) - LS-C240687 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (C-Terminus) IHC-plus™ - LS-A7246 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-SGK3 Antibody (aa7-36, PE) - LS-C240690 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa381-409, Azide-free, HRP) - LS-C248136 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SGK3 Antibody (aa7-36, Azide-free, HRP) - LS-C248137 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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