SGK3

Gene Symbol	SGK3
Entrez Gene	23678
Alt Symbol	CISK, SGK2, SGKL
Species	Human
Gene Type	protein-coding
Description	serum/glucocorticoid regulated kinase family, member 3
Other Description	cytokine-independent survival kinase|serine/threonine-protein kinase Sgk3
Swissprots	B3KQC2 A8K5W3 Q96BR1 Q9P1Q7 Q9UKG5
Accessions	CAF86721 CBX51345 EAW86919 EAW86920 Q96BR1 AF085233 AAF27051 AF169035 AAF12758 AI127772 AK074666 BAG51984 AK223523 BAD97243 AK291428 BAF84117 AV714643 BC015326 AAH15326 BF665552 BI547053 BM739201 BQ777590 BU177012 CB995805 CK822899 CR536581 CAG38818 CR933673 CAI45969 DB447859 NM_001033578 NP_001028750 NM_013257 NP_037389 NM_170709 NP_733827
Function	Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and
Subcellular Location	Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Tissue Specificity	Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER- positive breast tumors than ER-negative breast tumors. {ECO:0000269|PubMed:21084382}.
Top Pathways	PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SGK3 full length protein - ab55673 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human SGK3 full length protein - ab161746 from Abcam Category Protein Source Wheat germ Species Human

Human SGK3 full length protein - ab84767 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human SGK3 protein fragment - ab161747 from Abcam Category Protein Source Wheat germ Species Human

SGK3 Antibody Blocking Peptide - LS-E3155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SGK3 Antibody Blocking Peptide - LS-E9387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SGK3 Antibody Blocking Peptide - LS-E29244 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SGK3 Antibody Blocking Peptide - LS-E29245 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SGK3 Antibody Blocking Peptide - LS-E29246 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SGK3 Antibody Blocking Peptide - LS-E29247 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SGK3 Antibody Blocking Peptide - LS-E20104 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SGK3 Antibody Blocking Peptide - LS-E20103 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SGK3 Protein - H00023678-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SGK3 Protein - H00023678-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SGK3 Recombinant Protein - P4774 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

SGK3 Peptide - P2936 from Novus Biologicals Category Peptide Species Human

SGK3-Antibody-N-term-Blocking-Peptide - BP7949a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SGK3 His GST tag protein - orb84151 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

SGK3 Blocking Peptide - 33R-5569 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Sgk3 Blocking Peptide - 33R-9416 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SGK3 / SGKL - H00023678-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SGK3 / SGKL - H00023678-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SGK3 / SGKL - H00023678-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SGK3 / SGKL - P4774 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

SGK3 / SGKL - P5751 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

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