Irx3

Gene Symbol Irx3
Entrez Gene 16373
Alt Symbol AI894186
Species Mouse
Gene Type protein-coding
Description Iroquois related homeobox 3
Other Description homeodomain protein IRXB1|iroquois homeobox protein 3|iroquois-class homeodomain protein IRX-3
Swissprots Q3UPZ3 Q5U3K8 P81067
Accessions EDL11081 P81067 AK143023 BAE25251 BC020464 BC067195 BC085500 AAH85500 Y15001 CAA75233 NM_001253822 NP_001240751 NM_008393 NP_032419
Function Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. {ECO:0000269|PubMed:10830170, ECO:0000269|PubMed:15201216}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confined to the S3 segment of the proximal tubule, in the loop of Henle. {ECO:0000269|PubMed:10830170, ECO:0000269|PubMed:17875669}.

IRX3 CRISPR/Cas9 KO Plasmid (m) - sc-421155 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 HDR Plasmid (m) - sc-421155-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 Double Nickase Plasmid (m) - sc-421155-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 Double Nickase Plasmid (m2) - sc-421155-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 CRISPR Activation Plasmid (m) - sc-421155-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 CRISPR Activation Plasmid (m2) - sc-421155-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 Lentiviral Activation Particles (m) - sc-421155-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 Lentiviral Activation Particles (m2) - sc-421155-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

IRX3 siRNA (m) - sc-38704 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

IRX3 shRNA Plasmid (m) - sc-38704-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

IRX3 shRNA (m) Lentiviral Particles - sc-38704-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN33954 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33954 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IRX3 siRNA (Mouse) - CRM2105 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

IRX3 - MBS8227804 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse IRX3 (NM_008393.3) - SHH320825 from Creative biogene

Category siRNA
Species Reactivities Mouse

IRX3 shRNA Plasmid (Mouse) - CHM2105 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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