| Gene Symbol |
EBF2
|
| Entrez Gene |
64641
|
| Alt Symbol |
COE2, EBF-2, O/E-3, OE-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
early B-cell factor 2
|
| Other Description |
Collier, Olf and EBF 2|OLF-1/EBF-LIKE 3|metencephalon-mesencephalnon-olfactory transcription factor 1|transcription factor COE2
|
| Swissprots |
Q6ISA4 F5H645 A0PJM4 Q9HAK2 Q6IS86 A6NMF7 Q66VZ3 Q6DK36
|
| Accessions |
Q9HAK2 AI457889 AK001144 AK021562 BAB13843 AK093878 AK304372 BAH14170 AL701879 AU120738 AY700779 AAU10086 BC069665 AAH69665 BC069726 AAH69726 BC069747 AAH69747 BC069768 AAH69768 BC074794 AAH74794 BC113478 AAI13479 BC113504 AAI13505 BC137106 AAI37107 BC137107 AAI37108 BC148638 AAI48639 BQ878633 BY798905 NM_022659 NP_073150
|
| Function |
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|