Gene Symbol | CCDC176 |
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Entrez Gene | 80127 |
Alt Symbol | C14orf45 |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil domain containing 176 |
Other Description | basal body-orientation factor 1|coiled-coil domain-containing protein 176 |
Swissprots | Q8ND07 Q0P604 Q9H5P8 |
Accessions | EAW81157 Q8ND07 AK026842 BAB15572 AK097531 BAG53483 AL834487 CAD39145 BC044808 BC104979 AAI04980 BC104981 AAI04982 DB484577 DB493409 XM_005268092 XP_005268149 XM_005268097 XP_005268154 XM_005268098 XP_005268155 XM_011537170 XP_011535472 XM_011537171 XP_011535473 XM_011537172 XP_011535474 XM_011537173 XP_011535475 XM_011537174 XP_011535476 XM_011537175 XP_011535477 XM_011537176 XP_011535478 XM_011537177 XP_011535479 XM_011537178 XP_011535480 XM_011537179 XP_011535481 XM_011537180 XP_011535482 XR_245725 NM_025057 NP_079333 |
Function | Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Localizes to a polar structure adjacent to the basal body. {ECO:0000250}. |
C14orf45 CRISPR/Cas9 KO Plasmid (h) - sc-413340 from Santa Cruz Biotechnology
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C14orf45 HDR Plasmid (h) - sc-413340-HDR from Santa Cruz Biotechnology
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C14orf45 Double Nickase Plasmid (h) - sc-413340-NIC from Santa Cruz Biotechnology
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C14orf45 Double Nickase Plasmid (h2) - sc-413340-NIC-2 from Santa Cruz Biotechnology
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C14orf45 CRISPR Activation Plasmid (h) - sc-413340-ACT from Santa Cruz Biotechnology
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C14orf45 CRISPR Activation Plasmid (h2) - sc-413340-ACT-2 from Santa Cruz Biotechnology
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C14orf45 Lentiviral Activation Particles (h) - sc-413340-LAC from Santa Cruz Biotechnology
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C14orf45 Lentiviral Activation Particles (h2) - sc-413340-LAC-2 from Santa Cruz Biotechnology
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C14orf45 siRNA (h) - sc-92422 from Santa Cruz Biotechnology
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C14orf45 shRNA Plasmid (h) - sc-92422-SH from Santa Cruz Biotechnology
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C14orf45 shRNA (h) Lentiviral Particles - sc-92422-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4354 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4354 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09371 from Sigma-Aldrich
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CCDC176 siRNA (Human) - CRJ2760 from Cohesion Biosciences
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CCDC176 - MBS8213677 from MyBioSource
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shRNA set against Human C14orf45 (NM_025057.2) - SHH249470 from Creative biogene
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Human CCDC176 siRNA - orb273261 from Biorbyt
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CCDC176 shRNA Plasmid (Human) - CHJ2760 from Cohesion Biosciences
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CCDC176 miRNA 3'UTR clone - MiUTR1H-01120 from Creative biogene
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