| Gene Symbol |
CARD14
|
| Entrez Gene |
79092
|
| Alt Symbol |
BIMP2, CARMA2, PRP, PSORS2, PSS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 14
|
| Other Description |
CARD-containing MAGUK protein 2|bcl10-interacting maguk protein 2|caspase recruitment domain-containing protein 14
|
| Swissprots |
Q9BXL6 Q9BVB5 B8QQJ3
|
| Accessions |
EAW89586 EAW89587 EAW89588 EAW89589 Q9BXL6 AF322642 AAG53403 AK002138 AK054723 AK091123 AK095416 AK296762 BAG59342 AK309299 AX746790 AY032927 AAK54453 BC001326 AAH01326 BC018142 AAH18142 BU617627 DA461380 DB314596 EU652409 ACF49506 XM_011525212 XP_011523514 XM_011525213 XP_011523515 XM_011525214 XP_011523516 XM_011525215 XP_011523517 XM_011525216 XP_011523518 XM_011525217 XP_011523519 XM_011525218 XP_011523520 XM_011525219 XP_011523521 XM_011525220 XP_011523522 XM_011525221 XP_011523523 XM_011525222 XP_011523524 XM_011525223 XP_011523525 XR_934547 NM_001257970 NP_001244899 NM_024110 NP_077015 NM_052819 NP_438170 NR_047566
|
| Function |
Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. {ECO:0000269|PubMed:21302310}.
|
| Subcellular Location |
Isoform 3: Cytoplasm.
|
| Tissue Specificity |
Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain. {ECO:0000269|PubMed:22521418}.
|
![Western Blot: CARD14 Overexpression Lysate (Adult Normal) [NBP2-06347] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CARD14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6652_CARD14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06347-img0001.jpg)