Gene Symbol | CARD14 |
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Entrez Gene | 79092 |
Alt Symbol | BIMP2, CARMA2, PRP, PSORS2, PSS1 |
Species | Human |
Gene Type | protein-coding |
Description | caspase recruitment domain family, member 14 |
Other Description | CARD-containing MAGUK protein 2|bcl10-interacting maguk protein 2|caspase recruitment domain-containing protein 14 |
Swissprots | Q9BXL6 Q9BVB5 B8QQJ3 |
Accessions | EAW89586 EAW89587 EAW89588 EAW89589 Q9BXL6 AF322642 AAG53403 AK002138 AK054723 AK091123 AK095416 AK296762 BAG59342 AK309299 AX746790 AY032927 AAK54453 BC001326 AAH01326 BC018142 AAH18142 BU617627 DA461380 DB314596 EU652409 ACF49506 XM_011525212 XP_011523514 XM_011525213 XP_011523515 XM_011525214 XP_011523516 XM_011525215 XP_011523517 XM_011525216 XP_011523518 XM_011525217 XP_011523519 XM_011525218 XP_011523520 XM_011525219 XP_011523521 XM_011525220 XP_011523522 XM_011525221 XP_011523523 XM_011525222 XP_011523524 XM_011525223 XP_011523525 XR_934547 NM_001257970 NP_001244899 NM_024110 NP_077015 NM_052819 NP_438170 NR_047566 |
Function | Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. {ECO:0000269|PubMed:21302310}. |
Subcellular Location | Isoform 3: Cytoplasm. |
Tissue Specificity | Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain. {ECO:0000269|PubMed:22521418}. |
CARD 14 CRISPR/Cas9 KO Plasmid (h) - sc-410117 from Santa Cruz Biotechnology
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CARD 14 HDR Plasmid (h) - sc-410117-HDR from Santa Cruz Biotechnology
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CARD 14 Double Nickase Plasmid (h) - sc-410117-NIC from Santa Cruz Biotechnology
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CARD 14 Double Nickase Plasmid (h2) - sc-410117-NIC-2 from Santa Cruz Biotechnology
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CARD 14 CRISPR Activation Plasmid (h) - sc-410117-ACT from Santa Cruz Biotechnology
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CARD 14 CRISPR Activation Plasmid (h2) - sc-410117-ACT-2 from Santa Cruz Biotechnology
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CARD 14 Lentiviral Activation Particles (h) - sc-410117-LAC from Santa Cruz Biotechnology
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CARD 14 Lentiviral Activation Particles (h2) - sc-410117-LAC-2 from Santa Cruz Biotechnology
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CARD 14 siRNA (h) - sc-60330 from Santa Cruz Biotechnology
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CARD 14 shRNA Plasmid (h) - sc-60330-SH from Santa Cruz Biotechnology
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CARD 14 shRNA (h) Lentiviral Particles - sc-60330-V from Santa Cruz Biotechnology
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CARD14 RNAi - H00079092-R02 from Novus Biologicals
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MISSION® siRNA - SIHK0274 from Sigma-Aldrich
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MISSION® siRNA - SIHK0273 from Sigma-Aldrich
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MISSION® siRNA - SIHK0275 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5363 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5363 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00381 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05873 from Sigma-Aldrich
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CARD14 siRNA (Human) - CRJ2308 from Cohesion Biosciences
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CARD14 RNAi - H00079092-R01 from Novus Biologicals
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CARD14 - MBS8228860 from MyBioSource
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shRNA set against Human CARD14 (NM_024110.4) - SHH254693 from Creative biogene
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Human CARD14 siRNA - orb272809 from Biorbyt
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CARD14 shRNA Plasmid (Human) - CHJ2308 from Cohesion Biosciences
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