IFIT1

Gene Symbol	IFIT1
Entrez Gene	3434
Alt Symbol	C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
Species	Human
Gene Type	protein-coding
Description	interferon-induced protein with tetratricopeptide repeats 1
Other Description	interferon, alpha-inducible protein (MW 56kD)|interferon-induced 56 kDa protein|interferon-inducible mRNA 561
Swissprots	B3KS50 Q96QM5 Q5T7J1 P09914 D3DR31
Accessions	CAA29802 EAW50136 EAW50137 EAW50138 P09914 AK092813 BAG52612 AK308688 AK314588 BAG37163 AL548182 AL711085 BC007091 AAH07091 BI670242 BT006667 AAP35313 BU625391 CA306581 CD106320 DA822484 DB003897 DB180094 DB474377 DQ893534 ABM84460 DQ893755 ABM84681 X03557 CAA27244 NM_001270927 NP_001257856 NM_001270928 NP_001257857 NM_001270929 NP_001257858 NM_001270930 NP_001257859 NM_001548 NP_001539
Function	Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}.
Top Pathways	Hepatitis C, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IFIT1 full length protein - ab152468 from Abcam Category Protein Source Wheat germ Species Human

Human IFIT1 protein fragment - ab114512 from Abcam Category Protein Source Wheat germ Species Human

IFIT1 / ISG56 Antibody Blocking Peptide - LS-E25043 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IFIT1 / ISG56 Antibody Blocking Peptide - LS-E22505 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IFIT1 Protein - H00003434-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IFIT1 Protein - H00003434-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IFI56 / IFIT1 - H00003434-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

IFI56 / IFIT1 - H00003434-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IFI56 / IFIT1 - H00003434-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IFIT1 Peptide - 7757P from ProSci Category Peptide Species Human

IFIT1 fusion protein - ag19445 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IFIT1 fusion protein - Ag19691 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human IFIT1 - IFIT1-26949TH from Creative Biomart Category Protein Source Wheat germ Species Human

IFI-56K (H63) Peptide - BS3033P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Interferon-induced protein with tetratricopeptide repeats 1(IFIT1) - CSB-YP011018HU CSB-EP011018HU CSB-BP011018HU CSB-MP011018HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IFI56 / IFIT1 (transcript variant 2) - TP303320 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IFIT1 Protein - NBP2-33751PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

IFIT1 Peptide, Human - M34GP07426H from Creative Peptides Category Peptide Source Synthetic. Species Human

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), Recombinant Protein - MBS951163 from MyBioSource Category Protein Prices $1,260.00, $1,260.00, $1,480.00, $1,480.00, $2,060.00, $2,060.00, $2,525.00, $2,525.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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