| Gene Symbol | IFIT1 |
|---|---|
| Entrez Gene | 3434 |
| Alt Symbol | C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon-induced protein with tetratricopeptide repeats 1 |
| Other Description | interferon, alpha-inducible protein (MW 56kD)|interferon-induced 56 kDa protein|interferon-inducible mRNA 561 |
| Swissprots | B3KS50 Q96QM5 Q5T7J1 P09914 D3DR31 |
| Accessions | CAA29802 EAW50136 EAW50137 EAW50138 P09914 AK092813 BAG52612 AK308688 AK314588 BAG37163 AL548182 AL711085 BC007091 AAH07091 BI670242 BT006667 AAP35313 BU625391 CA306581 CD106320 DA822484 DB003897 DB180094 DB474377 DQ893534 ABM84460 DQ893755 ABM84681 X03557 CAA27244 NM_001270927 NP_001257856 NM_001270928 NP_001257857 NM_001270929 NP_001257858 NM_001270930 NP_001257859 NM_001548 NP_001539 |
| Function | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}. |
| Top Pathways | Hepatitis C, Herpes simplex infection |
IFIT1 CRISPR/Cas9 KO Plasmid (h) - sc-403066 from Santa Cruz Biotechnology
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IFIT1 HDR Plasmid (h) - sc-403066-HDR from Santa Cruz Biotechnology
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IFIT1 Double Nickase Plasmid (h) - sc-403066-NIC from Santa Cruz Biotechnology
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IFIT1 Double Nickase Plasmid (h2) - sc-403066-NIC-2 from Santa Cruz Biotechnology
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IFIT1 CRISPR Activation Plasmid (h) - sc-403066-ACT from Santa Cruz Biotechnology
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IFIT1 CRISPR Activation Plasmid (h2) - sc-403066-ACT-2 from Santa Cruz Biotechnology
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IFIT1 Lentiviral Activation Particles (h) - sc-403066-LAC from Santa Cruz Biotechnology
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IFIT1 Lentiviral Activation Particles (h2) - sc-403066-LAC-2 from Santa Cruz Biotechnology
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IFIT1 siRNA (h) - sc-75322 from Santa Cruz Biotechnology
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IFIT1 shRNA Plasmid (h) - sc-75322-SH from Santa Cruz Biotechnology
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IFIT1 shRNA (h) Lentiviral Particles - sc-75322-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU143151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10465 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10465 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01990 from Sigma-Aldrich
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IFIT1 siRNA (Human) - CRH2326 from Cohesion Biosciences
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IFIT1 - MBS8220436 from MyBioSource
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shRNA set against Human IFIT1 (NM_001548.4) - SHH316905 from Creative biogene
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Human IFIT1 siRNA - orb262828 from Biorbyt
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IFIT1 shRNA Plasmid (Human) - CHH2326 from Cohesion Biosciences
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IFIT1 miRNA 3'UTR clone - MiUTR3H-01239 from Creative biogene
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