| Gene Symbol |
ACTR3B
|
| Entrez Gene |
57180
|
| Alt Symbol |
ARP11, ARP3BETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ARP3 actin-related protein 3 homolog B (yeast)
|
| Other Description |
ARP3-beta|actin-like protein 3B|actin-related protein 3-beta|actin-related protein 3B|actin-related protein ARP4|actin-related protein Arp11
|
| Swissprots |
A8MTG1 Q96BT2 Q7Z526 Q9P1U1 B4DFW4
|
| Accessions |
AAS07430 EAW80446 Q9P1U1 AA559050 AB209174 BAD92411 AF023453 AAC98904 AF086920 AAP97150 AK001198 BAG50867 AK294292 BAG57575 AK315534 BAG37914 AK316078 BAH14449 BC008682 AAH08682 BC015207 AAH15207 DB570472 DN601600 DQ894754 ABM85680 EU176295 ABW03746 XM_006716065 XP_006716128 XM_006716066 XP_006716129 XM_006716067 XP_006716130 XM_006716068 XP_006716131 XM_011516425 XP_011514727 XM_011516426 XP_011514728 XM_011516427 XP_011514729 XM_011516428 XP_011514730 XR_927492 NM_001040135 NP_001035225 NM_020445 NP_065178 NR_073000 NR_073001
|
| Function |
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
|
| Tissue Specificity |
Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential. {ECO:0000269|PubMed:10806390, ECO:0000269|PubMed:11162478}.
|