LGI1

Gene Symbol LGI1
Entrez Gene 9211
Alt Symbol ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
Species Human
Gene Type protein-coding
Description leucine-rich, glioma inactivated 1
Other Description epitempin-1|leucine-rich glioma-inactivated protein 1
Swissprots Q5W001 O95970 Q5W002 B4E1S0 Q96LF5 A8K0Z1 Q8NI23
Accessions CAI93453 EAW50051 EAW50052 EAW50053 O95970 AB209408 BAD92645 AF055636 AAC99316 AF473548 AAM22074 AK289706 BAF82395 AK303956 BAG64882 AK309416 AY358885 AAQ89244 BC022500 AAH22500 DB546258 DC326684 DQ892371 ABM83297 DQ895580 ABM86506 H05384 XM_005270272 XP_005270329 NM_001308275 NP_001295204 NM_001308276 NP_001295205 NM_005097 NP_005088 NR_131777
Function Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. {ECO:0000250, ECO:0000269|PubMed:15047712, ECO:0000269|PubMed:16518856}.
Subcellular Location Secreted {ECO:0000269|PubMed:16787412, ECO:0000269|PubMed:17067999, ECO:0000269|PubMed:17296837}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.
Tissue Specificity Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level). {ECO:0000269|PubMed:16518856, ECO:0000269|PubMed:16787412}.

Human Lgi1 full length protein - ab152963 from Abcam

Category Protein
Source Wheat germ
Species Human
ab152963 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Rat Lgi1 peptide - ab33114 from Abcam

Category Peptide

LGI1 Antibody Blocking Peptide - LS-E22478 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

LGI1 Antibody Blocking Peptide - LS-E30457 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

LGI1 Antibody Blocking Peptide - LS-E30469 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human Lgi1 Protein - H00009211-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human
Recombinant Human Lgi1 Protein [H00009211-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.

Lgi1 Blocking Peptide - NBP1-76379PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human
Western Blot: Lgi1 Peptide [NBP1-76379PEP] - blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.

Lgi1 Blocking Peptide - NBP1-77320PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human

LGI1 / EPT - H00009211-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

LGI1 / EPT Control Peptide - AP30496CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

LGI1 / EPT Control Peptide - AP30497CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

LGI1 Peptide - 4489P from ProSci

Category Peptide
Species Human

LGI1 Peptide - 4531P from ProSci

Category Peptide
Species Human
Western blot analysis of LGI1 in mouse brain tissue lysate with LGI1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

LGI1 fusion protein - ag3184 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Leucine-rich glioma-inactivated protein 1(LGI1) - CSB-YP012898HU CSB-EP012898HU CSB-BP012898HU CSB-MP012898HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

LGI1 Protein - abx164175 from Abbexa

Category Protein
Species Human, Mouse, Rat

LGI1-Antibody-Center-Blocking-Peptide - BP6769c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

LGI1 Peptide, Human - M34GP08668H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Leucine-rich glioma-inactivated protein 1 (LGI1), Recombinant Protein - MBS1017438 from MyBioSource

Category Protein
Prices $1,315.00, $1,315.00, $1,530.00, $1,530.00, $2,165.00, $2,165.00, $2,630.00, $2,630.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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