LGI1

Gene Symbol	LGI1
Entrez Gene	9211
Alt Symbol	ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
Species	Human
Gene Type	protein-coding
Description	leucine-rich, glioma inactivated 1
Other Description	epitempin-1\|leucine-rich glioma-inactivated protein 1
Swissprots	Q5W001 O95970 Q5W002 B4E1S0 Q96LF5 A8K0Z1 Q8NI23
Accessions	CAI93453 EAW50051 EAW50052 EAW50053 O95970 AB209408 BAD92645 AF055636 AAC99316 AF473548 AAM22074 AK289706 BAF82395 AK303956 BAG64882 AK309416 AY358885 AAQ89244 BC022500 AAH22500 DB546258 DC326684 DQ892371 ABM83297 DQ895580 ABM86506 H05384 XM_005270272 XP_005270329 NM_001308275 NP_001295204 NM_001308276 NP_001295205 NM_005097 NP_005088 NR_131777
Function	Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. {ECO:0000250, ECO:0000269\|PubMed:15047712, ECO:0000269\|PubMed:16518856}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:16787412, ECO:0000269\|PubMed:17067999, ECO:0000269\|PubMed:17296837}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.
Tissue Specificity	Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level). {ECO:0000269\|PubMed:16518856, ECO:0000269\|PubMed:16787412}.

LGI1 (N-18) - sc-9581 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LGI1 (N-18): sc-9581. Western blot analysis of LGI1 expression in rat (A) and mouse (B) brain extracts.

LGI1 (H-56) - sc-28238 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

LGI1 (H-56): sc-28238. Western blot analysis of LGI1 expression in non-transfected: sc-117752 (A) and human LGI1 transfected: sc-172088 (B) 293T whole cell lysates.

LGI1 (C-19) - sc-9583 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LGI1 (C-19): sc-9583. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells, cytoplasmic and membrane staining of cells in granular layer and neuropil staining in molecular layer.

Anti-Lgi1 antibody - ab30868 from Abcam

Prices	$400.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Lgi1 antibody (ab30868) at 1/1000 dilution + Rat brain tissue lysate at 30 µgSecondaryHRP-conjugate Goat anti-rabbit IgG polyclonal at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Lgi1 antibody - ab67319 from Abcam

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Lgi1 antibody (ab67319) at 2 µg/ml + HeLa cell lysate at 15 µg

Anti-Lgi1 antibody - ab69491 from Abcam

Prices	$388.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Lgi1 antibody (ab69491) at 1 µg/mlLane 1 : mouse brain tissue lysateLane 2 : mouse brain tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-Lgi1 antibody - ab168933 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-Lgi1 antibody (ab168933) at 1 µg/mlLane 1 : Lgi1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Lgi1 antibody [EPR9084] - ab137045 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR9084

All lanes : Anti-Lgi1 antibody [EPR9084] (ab137045) at 1/1000 dilutionLane 1 : Human brain lysateLane 2 : HeLa lysateLane 3 : U87-MG lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti Rabbit IgG at 1/2000 dilution

Anti-Lgi1 antibody [S283-7] (FITC) - ab186274 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S283-7

Anti-Lgi1 antibody [S283-7] (HRP) - ab186309 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S283-7

Anti-Lgi1 antibody [S2837] - ab186296 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S2837

Anti-Lgi1 antibody [S2837] (Biotin) - ab186263 from Abcam

Prices	$372.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S2837

Anti-LGI1 Antibody - LS-C309172 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-LGI1 Antibody (aa37-113, clone S283-7) - LS-C209549 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S283-7

Anti-LGI1 Antibody - LS-C341787 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LGI1 Antibody (aa25-74) - LS-C145344 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LGI1 antibody LS-C145344 Western blot of HCT15 Cell lysate. Antibody concentration 1 ug/ml.

Anti-LGI1 Antibody (N-Terminus) - LS-C53277 from LifeSpan Bioscience

Prices	$325.00, $890.00
Sizes	50 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of LGI1 in mouse brain tissue lysate with LGI1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Anti-LGI1 Antibody (Internal) - LS-C53265 from LifeSpan Bioscience

Prices	$345.00, $1,035.00
Sizes	50 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of LGI1 in Human Brain cells with LGI1 antibody at 20 ug/ml.

Lgi1 Antibody - NBP1-77320 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Lgi1 Antibody [NBP1-77320] - HeLa cell lysate with LGI1 antibody at 2 ug/ml.

Lgi1 Antibody - NBP1-76379 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Lgi1 Antibody [NBP1-76379] - Mouse brain tissue lysate with LGI1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Lgi1 Antibody - NBP1-33087 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Lgi1 Antibody [NBP1-33087] - Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE, antibody diluted at 1:5000.

LGI1 Polyclonal Antibody - bs-6719R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti LGI1/ETL1 Polyclonal Antibody, Unconjugated (bs-6719R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-LGI1 antibody produced in rabbit - HPA054482 from Sigma-Aldrich

Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-LGI1: <B>Cat. No. HPA054482</B>: Immunohistochemical staining of human cerebral cortex shows strong positivity in neuronal cells.

Anti-LGI1 (ab1) antibody produced in rabbit - PRS4489 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-LGI1: <B>Cat. No. PRS4489</B> Immunohistochemical staining of human brain tissue using LGI1 antibody at 2.5 μg/mL.

Anti-LGI1 antibody produced in mouse - SAB1406794 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-LGI1: <B>Cat. No. SAB1406794</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~61.3 kDa using LGI1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

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