| Gene Symbol |
Gls2
|
| Entrez Gene |
192268
|
| Alt Symbol |
Ga
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutaminase 2 (liver, mitochondrial)
|
| Other Description |
GLS|L-glutaminase|L-glutamine amidohydrolase|glutaminase liver isoform, mitochondrial|liver mitochondrial glutaminase
|
| Swissprots |
Q64606 Q5FVU0 P28492 Q3MHS6
|
| Accessions |
EDL84884 EDL84885 P28492 BC089776 AAH89776 BC104712 AAI04713 FQ211735 J05499 AAC37707 XM_006240728 XP_006240790 XM_006240730 XP_006240792 NM_001270786 NP_001257715 NM_001270787 NP_001257716 NM_138904 NP_620259
|
| Function |
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion.
|
| Tissue Specificity |
Liver specific.
|
| Top Pathways |
Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation
|
