| Gene Symbol | Gls2 |
|---|---|
| Entrez Gene | 192268 |
| Alt Symbol | Ga |
| Species | Rat |
| Gene Type | protein-coding |
| Description | glutaminase 2 (liver, mitochondrial) |
| Other Description | GLS|L-glutaminase|L-glutamine amidohydrolase|glutaminase liver isoform, mitochondrial|liver mitochondrial glutaminase |
| Swissprots | Q64606 Q5FVU0 P28492 Q3MHS6 |
| Accessions | EDL84884 EDL84885 P28492 BC089776 AAH89776 BC104712 AAI04713 FQ211735 J05499 AAC37707 XM_006240728 XP_006240790 XM_006240730 XP_006240792 NM_001270786 NP_001257715 NM_001270787 NP_001257716 NM_138904 NP_620259 |
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion. |
| Tissue Specificity | Liver specific. |
| Top Pathways | Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation |
Gls siRNA (r) - sc-270166 from Santa Cruz Biotechnology
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Gls shRNA Plasmid (r) - sc-270166-SH from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN54495 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND54495 from Sigma-Aldrich
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GLS2 siRNA (Rat) - CRR3524 from Cohesion Biosciences
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GLS2 - MBS8220009 from MyBioSource
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shRNA set against Rat GLS2 (NM_138904.2) - SHH302058 from Creative biogene
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GLS2 shRNA Plasmid (Rat) - CHR3524 from Cohesion Biosciences
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