Gene Symbol | TECTA |
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Entrez Gene | 7007 |
Alt Symbol | DFNA12, DFNA8, DFNB21 |
Species | Human |
Gene Type | protein-coding |
Description | tectorin alpha |
Other Description | alpha-tectorin |
Swissprots | O75443 |
Accessions | AAC26019 CCQ43320 EAW67516 EAW67517 EAW67518 O75443 AF143331 BC156465 AAI56466 BC172509 AAI72509 NM_005422 NP_005413 |
Function | One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}. |
α-tectorin CRISPR/Cas9 KO Plasmid (h) - sc-405876 from Santa Cruz Biotechnology
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α-tectorin HDR Plasmid (h) - sc-405876-HDR from Santa Cruz Biotechnology
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α-tectorin Double Nickase Plasmid (h) - sc-405876-NIC from Santa Cruz Biotechnology
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α-tectorin Double Nickase Plasmid (h2) - sc-405876-NIC-2 from Santa Cruz Biotechnology
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α-tectorin CRISPR Activation Plasmid (h) - sc-405876-ACT from Santa Cruz Biotechnology
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α-tectorin CRISPR Activation Plasmid (h2) - sc-405876-ACT-2 from Santa Cruz Biotechnology
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α-tectorin Lentiviral Activation Particles (h) - sc-405876-LAC from Santa Cruz Biotechnology
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α-tectorin Lentiviral Activation Particles (h2) - sc-405876-LAC-2 from Santa Cruz Biotechnology
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α-tectorin siRNA (h) - sc-45730 from Santa Cruz Biotechnology
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α-tectorin shRNA Plasmid (h) - sc-45730-SH from Santa Cruz Biotechnology
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α-tectorin shRNA (h) Lentiviral Particles - sc-45730-V from Santa Cruz Biotechnology
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Tectorin alpha RNAi - H00007007-R01 from Novus Biologicals
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MISSION® esiRNA - EHU018651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21204 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21204 from Sigma-Aldrich
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TECTA siRNA (Human) - CRH4784 from Cohesion Biosciences
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TECTA - MBS8236526 from MyBioSource
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α-tectorin CRISPR/Cas9 KO Plasmid (h2) - sc-405876-KO-2 from Santa Cruz Biotechnology
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α-tectorin HDR Plasmid (h2) - sc-405876-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TECTA (NM_005422.2) - SHH425532 from Creative biogene
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Human TECTA siRNA - orb265286 from Biorbyt
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TECTA shRNA Plasmid (Human) - CHH4784 from Cohesion Biosciences
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TECTA miRNA 3'UTR clone - MiUTR4H-TG12594 from Creative biogene
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