| Gene Symbol | PSMC2 |
|---|---|
| Entrez Gene | 5701 |
| Alt Symbol | MSS1, Nbla10058, S7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) 26S subunit, ATPase, 2 |
| Other Description | 26S protease regulatory subunit 7|26S proteasome AAA-ATPase subunit RPT1|mammalian suppressor of sgv-1 of yeast|protease 26S subunit 7|proteasome 26S subunit ATPase 2|proteasome 26S subunit, ATPase, 2|putative protein product of Nbla10058 |
| Swissprots | P35998 Q9UDI3 B7Z5E2 Q3LIA5 A4D0Q1 |
| Accessions | AAS07429 EAL24412 EAW83331 EAW83332 EAW83333 P35998 AB075520 BAE45763 AK298529 BAH12807 AK298821 BAH12878 AK312648 BC002589 AAH02589 BE269755 BM754312 BU675889 D11094 BAA01868 EU446703 ABZ92232 XM_005250505 XP_005250562 NM_001204453 NP_001191382 NM_002803 NP_002794 |
| Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. {ECO:0000269|PubMed:9295362}. |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
| Top Pathways | Proteasome, Epstein-Barr virus infection |