| Gene Symbol |
PSMC2
|
| Entrez Gene |
5701
|
| Alt Symbol |
MSS1, Nbla10058, S7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) 26S subunit, ATPase, 2
|
| Other Description |
26S protease regulatory subunit 7|26S proteasome AAA-ATPase subunit RPT1|mammalian suppressor of sgv-1 of yeast|protease 26S subunit 7|proteasome 26S subunit ATPase 2|proteasome 26S subunit, ATPase, 2|putative protein product of Nbla10058
|
| Swissprots |
P35998 Q9UDI3 B7Z5E2 Q3LIA5 A4D0Q1
|
| Accessions |
AAS07429 EAL24412 EAW83331 EAW83332 EAW83333 P35998 AB075520 BAE45763 AK298529 BAH12807 AK298821 BAH12878 AK312648 BC002589 AAH02589 BE269755 BM754312 BU675889 D11094 BAA01868 EU446703 ABZ92232 XM_005250505 XP_005250562 NM_001204453 NP_001191382 NM_002803 NP_002794
|
| Function |
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. {ECO:0000269|PubMed:9295362}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
|
| Top Pathways |
Proteasome, Epstein-Barr virus infection
|
