Gene Symbol | PSMC2 |
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Entrez Gene | 5701 |
Alt Symbol | MSS1, Nbla10058, S7 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) 26S subunit, ATPase, 2 |
Other Description | 26S protease regulatory subunit 7|26S proteasome AAA-ATPase subunit RPT1|mammalian suppressor of sgv-1 of yeast|protease 26S subunit 7|proteasome 26S subunit ATPase 2|proteasome 26S subunit, ATPase, 2|putative protein product of Nbla10058 |
Swissprots | P35998 Q9UDI3 B7Z5E2 Q3LIA5 A4D0Q1 |
Accessions | AAS07429 EAL24412 EAW83331 EAW83332 EAW83333 P35998 AB075520 BAE45763 AK298529 BAH12807 AK298821 BAH12878 AK312648 BC002589 AAH02589 BE269755 BM754312 BU675889 D11094 BAA01868 EU446703 ABZ92232 XM_005250505 XP_005250562 NM_001204453 NP_001191382 NM_002803 NP_002794 |
Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. {ECO:0000269|PubMed:9295362}. |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
Top Pathways | Proteasome, Epstein-Barr virus infection |
PSMC2 CRISPR/Cas9 KO Plasmid (h) - sc-405022 from Santa Cruz Biotechnology
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PSMC2 HDR Plasmid (h) - sc-405022-HDR from Santa Cruz Biotechnology
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PSMC2 Double Nickase Plasmid (h) - sc-405022-NIC from Santa Cruz Biotechnology
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PSMC2 Double Nickase Plasmid (h2) - sc-405022-NIC-2 from Santa Cruz Biotechnology
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PSMC2 CRISPR Activation Plasmid (h) - sc-405022-ACT from Santa Cruz Biotechnology
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PSMC2 CRISPR Activation Plasmid (h2) - sc-405022-ACT-2 from Santa Cruz Biotechnology
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PSMC2 Lentiviral Activation Particles (h) - sc-405022-LAC from Santa Cruz Biotechnology
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PSMC2 Lentiviral Activation Particles (h2) - sc-405022-LAC-2 from Santa Cruz Biotechnology
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PSMC2 siRNA (h) - sc-76273 from Santa Cruz Biotechnology
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PSMC2 shRNA Plasmid (h) - sc-76273-SH from Santa Cruz Biotechnology
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PSMC2 shRNA (h) Lentiviral Particles - sc-76273-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU048051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17608 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17608 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00457 from Sigma-Aldrich
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PSMC2 siRNA (Human) - CRH3848 from Cohesion Biosciences
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Proteasome 19S S7 RNAi - H00005701-R01 from Novus Biologicals
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shRNA set against Human PSMC2 (NM_002803.3) - SHH385276 from Creative biogene
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Human PSMC2 siRNA - orb264350 from Biorbyt
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PSMC2 shRNA Plasmid (Human) - CHH3848 from Cohesion Biosciences
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PSMC2 miRNA 3'UTR clone - MiUTR3H-01378 from Creative biogene
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