| Gene Symbol |
H1foo
|
| Entrez Gene |
171506
|
| Alt Symbol |
C86609, H1.8, H1fo, H1oo
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
H1 histone family, member O, oocyte-specific
|
| Other Description |
histone H1oo|oocyte-specific histone H1|oocyte-specific linker histone H1
|
| Swissprots |
Q8VIK3
|
| Accessions |
EDK99547 Q8VIK3 AK135944 BAE22736 AK162137 BAE36747 AK162154 AK165127 AY007195 AAG01890 BC137916 AAI37917 BC145046 XM_006505678 XP_006505741 NM_138311 NP_612184
|
| Function |
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. {ECO:0000269|PubMed:11171391, ECO:0000269|PubMed:14729479, ECO:0000269|PubMed:15371275, ECO:0000269|PubMed:17519519}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo.
|
| Tissue Specificity |
Oocyte-specific. {ECO:0000269|PubMed:11171391, ECO:0000269|PubMed:15371275}.
|