| Gene Symbol |
DSC1
|
| Entrez Gene |
1823
|
| Alt Symbol |
CDHF1, DG2/DG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
desmocollin 1
|
| Other Description |
cadherin family member 1|desmocollin-1|desmosomal glycoprotein 2/3
|
| Swissprots |
Q08554 Q9HB01
|
| Accessions |
AAG23424 AAG23425 EAX01252 EAX01253 Q08554 BC148349 AAI48350 CU444724 CU447407 X72925 CAA51428 Z34522 CAA84278 NM_004948 NP_004939 NM_024421 NP_077739
|
| Function |
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
|
| Tissue Specificity |
Strongly expressed in epidermis, less in lymph node and tongue.
|
![Western Blot: Desmocollin 1 Overexpression Lysate (Native) [NBP2-06335] - Desmocollin 1 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Desmosomal Protein.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2081_Desmocollin-1-Overexpression-Lysate-(Native)-Western-Blot-NBP2-06335-img0002.jpg)