Gene Symbol | DSC1 |
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Entrez Gene | 1823 |
Alt Symbol | CDHF1, DG2/DG3 |
Species | Human |
Gene Type | protein-coding |
Description | desmocollin 1 |
Other Description | cadherin family member 1|desmocollin-1|desmosomal glycoprotein 2/3 |
Swissprots | Q08554 Q9HB01 |
Accessions | AAG23424 AAG23425 EAX01252 EAX01253 Q08554 BC148349 AAI48350 CU444724 CU447407 X72925 CAA51428 Z34522 CAA84278 NM_004948 NP_004939 NM_024421 NP_077739 |
Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. |
Tissue Specificity | Strongly expressed in epidermis, less in lymph node and tongue. |
DSC1 CRISPR/Cas9 KO Plasmid (h) - sc-402944 from Santa Cruz Biotechnology
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DSC1 HDR Plasmid (h) - sc-402944-HDR from Santa Cruz Biotechnology
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DSC1 Double Nickase Plasmid (h) - sc-402944-NIC from Santa Cruz Biotechnology
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DSC1 Double Nickase Plasmid (h2) - sc-402944-NIC-2 from Santa Cruz Biotechnology
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DSC1 CRISPR Activation Plasmid (h) - sc-402944-ACT from Santa Cruz Biotechnology
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DSC1 CRISPR Activation Plasmid (h2) - sc-402944-ACT-2 from Santa Cruz Biotechnology
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DSC1 Lentiviral Activation Particles (h) - sc-402944-LAC from Santa Cruz Biotechnology
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DSC1 Lentiviral Activation Particles (h2) - sc-402944-LAC-2 from Santa Cruz Biotechnology
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DSC1 siRNA (h) - sc-43733 from Santa Cruz Biotechnology
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DSC1 shRNA Plasmid (h) - sc-43733-SH from Santa Cruz Biotechnology
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DSC1 shRNA (h) Lentiviral Particles - sc-43733-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7495 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7495 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09814 from Sigma-Aldrich
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DSC1 siRNA (Human) - CRH1272 from Cohesion Biosciences
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Desmocollin-1 RNAi - H00001823-R01 from Novus Biologicals
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DSC1 - MBS8229788 from MyBioSource
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shRNA set against Human DSC1 (NM_004948.3) - SHH281117 from Creative biogene
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Human DSC1 siRNA - orb261774 from Biorbyt
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DSC1 shRNA Plasmid (Human) - CHH1272 from Cohesion Biosciences
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